Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus.
Neural substrates of verbal memory impairments in adults with type 2 diabetes mellitus.
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DOI：
10.1080/13803395.2013.869310
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发表时间：
2014
影响因子：
2.2
通讯作者：
Convit A
中科院分区：
文献类型：
--
作者：
Yau PL;Kluger A;Borod JC;Convit A
言语记忆障碍在2型糖尿病（T2DM）中有很好的记录，但迄今为止，神经基质仍不清楚。本研究评估了T2DM成人患者的言语记忆，并确定了额叶和颞叶参与预期言语记忆障碍的程度。46名中晚期和老年T2DM患者和50名年龄、性别和教育程度匹配的非T2DM患者接受了医学评价、言语记忆评估和脑MRI评价。正如预期的那样，T2DM参与者有明显的言语记忆障碍。与以前的报告一致，我们发现体积减少仅限于海马。我们的弥散张量成像分析显示，T2 DM受试者有广泛的大脑灰质和白色物质微结构异常，主要在左半球，颞叶有更大的浓度。相比之下，我们发现大多数非特异性的微结构异常，在额叶组织损失的情况下。非常重要的是，我们提出了T2DM参与者的第一个证据，将语言记忆障碍与左海马旁回（一个关键的记忆相关结构）的微结构完整性受损联系起来。我们的研究结果表明，海马和海马旁回可能特别容易受到T2DM的有害影响。特别是海马旁回可能在T2DM中经常报告的言语记忆障碍中起关键作用。未来的研究应采用静息态功能磁共振成像和弥散张量成像纤维束成像等方法，以更好地表征网络连接，这可能有助于进一步表征T2DM中经常报告的言语记忆障碍。
Verbal memory impairment is well documented in type 2 diabetes mellitus (T2DM) but to date, the neural substrates remain unclear. The present study evaluated verbal memory and ascertained the degree of frontal and temporal lobe involvement in the anticipated verbal memory impairment among adults with T2DM. Forty-six late middle-aged and elderly adults with T2DM and 50 age-, sex-, and education-matched adults without T2DM underwent medical evaluation, verbal memory assessment, and brain MRI evaluations. As anticipated, participants with T2DM had clear verbal memory impairments. Consistent with prior reports, we found volume reductions restricted to the hippocampus. Our diffusion tensor imaging analysis revealed that participants with T2DM had extensive cerebral gray and white matter microstructural abnormalities predominantly in the left hemisphere, with a larger concentration present in the temporal lobe. In contrast, we uncovered mostly non-specific microstructural abnormalities in the absence of tissue loss in the frontal lobe. Of great importance, we present the first evidence among participants with T2DM linking verbal memory impairment and compromised microstructural integrity of the left parahippocampal gyrus, a key memory-relevant structure. Our results suggest that the hippocampus and parahippocampal gyrus may be particularly vulnerable to the deleterious effects of T2DM. The parahippocampal gyrus in particular may play a crucial role in the verbal memory impairments frequently reported in T2DM. Future studies should employ methods such as resting state functional magnetic resonance imaging and diffusion tensor imaging tractography to better characterize network connectivity, which may help further characterize the verbal memory impairment frequently reported in T2DM.
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