Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders.
Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders.
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DOI：
10.1111/nure.12024
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发表时间：
2013-06
影响因子：
6.1
通讯作者：
Nagarkatti PS
中科院分区：
文献类型：
--
作者：
Busbee PB;Rouse M;Nagarkatti M;Nagarkatti PS
本综述的目的是讨论涉及芳烃受体 (AhR) 配体的研究及其在免疫调节中的作用。虽然众所周知，AhR 的激活能够调节环境化学物质的生化和毒性作用，但最近的一项令人兴奋的发现表明，AhR 连接还可以调节 T 细胞分化，特别是通过激活 Foxp3+ 调节性 T 细胞 (Treg) 和下调促炎性 Th17 细胞。这些发现为研究靶向 AhR 治疗炎症和自身免疫性疾病的可能性开辟了新途径。具体来说，本综述将讨论当前涉及天然和膳食 AhR 配体的研究。此外，还将强调表明这些配体在调节各种疾病的炎症方面的潜在用途的证据。 AhR 在免疫过程中的重要性可以通过该受体在大多数免疫细胞类型上的表达来说明。此外，据报道，AhR 信号通路会影响许多负责介导炎症和其他免疫反应的基因。随着人们对 AhR 及其配体的兴趣增加，巩固这些配体在炎症性疾病过程中对免疫调节的贡献的当前研究似乎是明智的。
The aim of this review is to discuss research involving ligands for the aryl hydrocarbon receptor (AhR) and their role in immunomodulation. While activation of the AhR is well known for its ability to regulate the biochemical and toxic effects of environmental chemicals, more recently an exciting discovery has been made indicating that AhR ligation can also regulate T-cell differentiation, specifically through activation of Foxp3+ regulatory T cells (Tregs) and downregulation of the proinflammatory Th17 cells. Such findings have opened new avenues of research on the possibility of targeting the AhR to treat inflammatory and autoimmune diseases. Specifically, this review will discuss the current research involving natural and dietary AhR ligands. In addition, evidence indicating the potential use of these ligands in regulating inflammation in various diseases will be highlighted. The importance of the AhR in immunological processes can be illustrated by expression of this receptor on a majority of immune cell types. In addition, AhR signaling pathways have been reported to influence a number of genes responsible for mediating inflammation and other immune responses. As interest in the AhR and its ligands increases, it seems prudent to consolidate current research on the contributions of these ligands to immune regulation during the course of inflammatory diseases.
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影响因子：
4.3
作者：
BRADFIELD, CA;BJELDANES, LF
通讯作者：
BJELDANES, LF
DOI：
10.1073/pnas.88.21.9543
发表时间：
1991-11-01
影响因子：
11.1
作者：
BJELDANES, LF;KIM, JY;BRADFIELD, CA
通讯作者：
BRADFIELD, CA
影响因子：
4.5
作者：
Camacho, IA;Hassuneh, MR;Nagarkatti, PS
通讯作者：
Nagarkatti, PS
影响因子：
64.8
作者：
Baur, Joseph A.;Pearson, Kevin J.;Sinclair, David A.
通讯作者：
Sinclair, David A.
影响因子：
3.6
作者：
Beedanagari, Sudheer R.;Taylor, Robert T.;Hankinson, Oliver
通讯作者：
Hankinson, Oliver