Post-translational modifications of exosomal proteins.
Post-translational modifications of exosomal proteins.
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DOI：
10.3389/fimmu.2014.00383
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发表时间：
2014
影响因子：
7.3
通讯作者：
Sánchez-Madrid F
中科院分区：
文献类型：
--
作者：
Moreno-Gonzalo O;Villarroya-Beltri C;Sánchez-Madrid F
外泌体介导细胞间通讯并参与许多细胞过程，如癌症进展、免疫激活或逃避以及感染扩散。外泌体是通过在多泡体（MVB）与质膜融合时释放这些MVB中所含的管腔内囊泡而分泌到细胞外环境的小囊泡。外泌体的组成不是随机的，这表明将货物掺入其中是一个受调控的过程。然而，控制将蛋白质货物分选到外泌体中的机制目前尚不清楚。在这里，我们回顾了外泌体蛋白中检测到的翻译后修饰，并讨论了它们在外泌体特异性分选中的可能作用。
Exosomes mediate intercellular communication and participate in many cell processes such as cancer progression, immune activation or evasion, and the spread of infection. Exosomes are small vesicles secreted to the extracellular environment through the release of intraluminal vesicles contained in multivesicular bodies (MVBs) upon the fusion of these MVBs with the plasma membrane. The composition of exosomes is not random, suggesting that the incorporation of cargo into them is a regulated process. However, the mechanisms that control the sorting of protein cargo into exosomes are currently elusive. Here, we review the post-translational modifications detected in exosomal proteins, and discuss their possible role in their specific sorting into exosomes.
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影响因子：
16
作者：
Bagola, Katrin;von Delbrueck, Maximilian;Sommer, Thomas
通讯作者：
Sommer, Thomas
影响因子：
3.7
作者：
Ikeda, Masato;Longnecker, Richard
通讯作者：
Longnecker, Richard
影响因子：
21.3
作者：
Hoeller, D;Crosetto, N;Dikic, I
通讯作者：
Dikic, I
影响因子：
3.7
作者：
Escrevente C;Grammel N;Kandzia S;Zeiser J;Tranfield EM;Conradt HS;Costa J
通讯作者：
Costa J
影响因子：
3.3
作者：
Erpapazoglou Z;Dhaoui M;Pantazopoulou M;Giordano F;Mari M;Léon S;Raposo G;Reggiori F;Haguenauer-Tsapis R
通讯作者：
Haguenauer-Tsapis R