An autopsy case of aortic dissection due to giant cell arteritis

An autopsy case of aortic dissection due to giant cell arteritis
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巨细胞动脉炎主动脉夹层尸检一例

DOI:
10.1111/pin.13046
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发表时间:
2021
影响因子:
2.2
通讯作者:
Sakamoto Noriaki
Sakamoto Noriaki
中科院分区:
医学4区
文献类型:
--
作者:
Sakashita Mai;Sakashita Shingo;Uesugi Noriko;Tokunaga Chiho;Hiramatsu Yuji;Noguchi Masayuki;Sakamoto Noriaki

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巨细胞动脉炎(GCA)是一种主要累及大中型动脉的系统性脉管炎。GCA有时会累及主动脉及其主要分支,并导致罕见的主动脉夹层。我们经历了一例因GCA引起的主动脉夹层的尸检病例。患者是一名87岁的日本女性,患有斯坦福A型主动脉夹层,入院7天后死亡。两年前,她被诊断为腹主动脉瘤,并接受了腔内动脉瘤修复术(EVAR)。虽然她没有GCA的特征症状,但尸检显示解剖区域和冠状动脉有明显的肉芽肿性炎症。活动性大动脉炎不仅见于上肢动脉,也见于下肢动脉。动脉瘤内肉芽肿性炎症不明显。主动脉夹层可能是GCA的最初表现。我们详细地报道了GCA延伸区及其组织学。
Giant cell arteritis (GCA) is a systemic vasculitis affecting mainly large and medium‐sized arteries. GCA sometimes involves the aorta and its major branches and causes aortic dissection as a rare complication. We have experienced an autopsy case of aortic dissection due to GCA. The patient was an 87‐year‐old Japanese woman with Stanford type A aortic dissection who died 7 days after admission. Two years previously she had been diagnosed as having abdominal aortic aneurysm and undergone endovascular aneurysm repair (EVAR). Although she had no characteristic symptoms of GCA, autopsy revealed marked granulomatous inflammation in the dissected area and coronary arteries. Active arteritis was evident not only in the arteries of the upper extremity but also those in the lower extremity. Granulomatous inflammation was not evident in the aneurysm. The aortic dissection might have been an initial manifestation of GCA. We report the regions of GCA extension and its histology in detail.
巨细胞动脉炎的主动脉夹层。
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