Accuracy of Visual Tests for Primary Cervical Cancer Screening in Rural Nepal.
Accuracy of Visual Tests for Primary Cervical Cancer Screening in Rural Nepal.
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DOI：
10.31729/jnma.3857
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发表时间：
2018-11
期刊：
影响因子：
--
通讯作者：
Cai H
中科院分区：
文献类型：
--
作者：
Thapa N;Maharjan M;Shrestha G;Maharjan N;Lindell D;Zuo N;Yang J;Maskey N;Cai H
在尼泊尔，宫颈癌是最常见的女性癌症。不幸的是，全国各地没有统一有效的筛查系统。本研究的目的是评价细胞学，目视检查与醋酸和卢戈碘单独或联合检测在尼泊尔农村的癌前病变。这是一项分析性的横断面研究。采用方便抽样技术，选择20 - 65岁的健康、已婚、未孕妇女参加宫颈癌筛查项目。在收集了社会人口统计学和生殖健康数据后，对所有符合条件的妇女（n = 2143）进行了筛查试验。将活检作为金标准试验。交叉表用于描述检测灵敏度、特异性、阳性预测值和阴性预测值（95%置信区间）。还计算了诊断优势比。大多数，2143（94%），妇女接受并参加了这项研究。细胞学、VIA和VILI的敏感性和特异性分别为57.1%和98.3%，71.4%和88.8%，78.6%和85.1%，"VIA和VILI均阳性"和"VIA或VILI均阳性"的联合检测的敏感性和特异性分别为64.3%和85.7%，90.1%和83.7%。所有试验的阴性预测值均超过99.7%。细胞学检查的诊断优势比最高（64.9），其次是联合检测“VIA或VILI阳性”（27.7）。宫颈癌筛查通过共同测试“无论是积极的VIA或VILI”是比细胞学更有用; VIA和/或VILI是简单，安全，可行和广泛接受的测试在低资源环境，尼泊尔。
In Nepal, cervical cancer is the most common female cancer. Unfortunately, there is no uniform effective screening system available all around the country. The objective of this study is to evaluate the cytology, Visual Inspection with Acetic Acid and with Lugol's Iodine alone or in combination to detect a pre-cancerous lesion in rural Nepal. It is an analytical cross-sectional study. Convenience sampling technique was used to select participants who were apparently healthy, married, non- pregnant women of aged 20–65 years for cervical cancer screening program. Screening tests were performed on all eligible women (n=2143) after socio-demographic and reproductive health data collection. A biopsy was applied as a gold standard test. Cross-tabulations were used to describe the test sensitivity, specificity, positive predictive value, and negative predictive value at a 95% confidence interval. Diagnostic odds ratio was also calculated. A majority, 2143 (94%), of women accepted and participated in this study. The sensitivity vs specificity of cytology, VIA, and VILI was 57.1% vs 98.3%, 71.4% vs 88.8% and 78.6% vs 85.1%, and of the co-testing of ‘Both positive VIA and VILI’ and ‘Either positive VIA or VILI’ was 64.3% vs 85.7% and 90.1% vs 83.7% respectively. Negative predictive value of all tests exceeded 99.7%. Cytology had the highest Diagnostic odds ratio (64.9), followed by the co-test ‘Either positive VIA or VILI’ (27.7). Cervical cancer screening by co-testing ‘Either positive VIA or VILI’ is more useful than cytology; VIA and or VILI are easy, safe, feasible and well-accepted tests in a low resource setting, Nepal.
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影响因子：
3.9
作者：
Thapa N;Shrestha G;Maharjan M;Lindell D;Maskey N;Shah R;Ge C;Cai H
通讯作者：
Cai H
DOI：
10.1016/j.ijgo.2015.11.019
发表时间：
2016-07-01
影响因子：
3.8
作者：
Ranjit, Anju;Gupta, Shailvi;Groen, Reinou S.
通讯作者：
Groen, Reinou S.
宫颈细胞学的准确性：在挪威三家医院中四名病理学家阅读的100张子宫颈抹片检查的诊断比较。
影响因子：
--
作者：
Sørbye SW;Suhrke P;Revå BW;Berland J;Maurseth RJ;Al-Shibli K
通讯作者：
Al-Shibli K
DOI：
10.1016/j.ijgo.2010.06.004
发表时间：
2010-11-01
影响因子：
3.8
作者：
Nessa, Ashrafun;Hussain, Muhammad Anwar;Sankaranarayanan, Rengaswamy
通讯作者：
Sankaranarayanan, Rengaswamy
影响因子：
3.9
作者：
Thapa N;Maharjan M;Petrini MA;Shah R;Shah S;Maharjan N;Shrestha N;Cai H
通讯作者：
Cai H