Burden of cervical neoplasia in mid-western rural Nepal: a population-based study.
Burden of cervical neoplasia in mid-western rural Nepal: a population-based study.
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DOI：
10.3802/jgo.2018.29.e64
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发表时间：
2018-09
影响因子：
3.9
通讯作者：
Cai H
中科院分区：
文献类型：
--
作者：
Thapa N;Shrestha G;Maharjan M;Lindell D;Maskey N;Shah R;Ge C;Cai H
采用细胞学、醋酸目视检查（VIA）和卢戈碘目视检查（VILI）评估尼泊尔中西部农村地区宫颈肿瘤的负担。进行了一项基于人群的横断面研究。2016年5月至2017年1月期间，共有2，279名年龄在20-65岁之间的已婚非妊娠女性参加了筛查诊所。所有符合条件的妇女完成自我报告的社会人口和生殖健康数据，然后进行筛查测试。从VIA和/或VILI评估为异常的宫颈区域获得活检。通过活检报告确认最终疾病。共有96.09%（n= 2，190）的女性有资格参加本研究，平均年龄为32.78±9.33岁。细胞学、VIA和VILI的总阳性率分别为3.69%、12.45%和16.89%。62例活检证实为宫颈癌。细胞学异常78例（3.69%），其中不典型鳞状细胞25例（1.18%），低度鳞状上皮内病变33例（1.56%），高度鳞状上皮内病变11例（0.52%），鳞状细胞癌9例（0.42%）。文盲妇女发生宫颈肿瘤的风险似乎更高（p<0.001）。同样，年龄≥46岁（p<0.013），参与者的多次婚姻或性伴侣（p<0.005）和人类免疫缺陷病毒阳性状态（p<0.001）与细胞学异常显著相关。根据细胞学报告，尼泊尔中西部农村地区妇女宫颈肿瘤的患病率为3.69%。“筛选和治疗”的方法在低资源环境中更具吸引力。
To assess the burden of cervical neoplasia in mid-western rural, Nepal using cytology, visual inspection with acetic acid (VIA) and visual inspection with Lugol's iodine (VILI). A cross-sectional, population-based study was conducted. Total of 2,279 married, non-pregnant women aged 20–65 years participated in a screening clinic from May 2016 to January 2017. All eligible women completed self-report of socio-demographic and reproductive health data followed by screening tests. Biopsies were obtained from areas on the cervix assessed by VIA and or VILI to be abnormal. Final disease was confirmed by biopsy report. A total of 96.09% (n=2,190) women were eligible for this study with mean age 32.78±9.33 years. The overall rate of positive cytology, VIA, and VILI were 3.69%, 12.45%, and 16.89%, respectively. Sixty-two cases were biopsy proven cervical neoplasia. Altogether 78 (3.69%) cases were cytologically abnormal: 25 (1.18%) were atypical squamous cells of undetermined significance, 33 (1.56%) were low-grade squamous intraepithelial lesion, 11 (0.52%) were high-grade squamous intraepithelial lesion, and 9 (0.42%) were squamous cell carcinoma. Illiterate women appeared to be at higher risk for cervical neoplasia (p<0.001). Similarly, age ≥46 years (p<0.013), participant's multiple marriages or sexual partners (p<0.005), and positive human immunodeficiency virus status (p<0.001) were significantly associated with abnormal cytology. Based on cytology report, there is 3.69% prevalence of cervical neoplasia among women in a rural region of mid-western, Nepal. A “screen and treat” approach would be more attractive in low resource settings.
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DOI：
10.1016/j.ijgo.2015.11.019
发表时间：
2016-07-01
影响因子：
3.8
作者：
Ranjit, Anju;Gupta, Shailvi;Groen, Reinou S.
通讯作者：
Groen, Reinou S.
影响因子：
3.7
作者：
Bhatta, Madhav P.;Johnson, Derek C.;Shrestha, Sadeep
通讯作者：
Shrestha, Sadeep
影响因子：
2.3
作者：
Sherpa, Ang Tshering Lama;Clifford, Gary M.;Franceschi, Silvia
通讯作者：
Franceschi, Silvia
影响因子：
8.8
作者：
Louie, K. S.;de Sanjose, S.;Diaz, M.;Castellsague, X.;Herrero, R.;Meijer, C. J.;Shah, K.;Franceschi, S.;Munoz, N.;Bosch, F. X.
通讯作者：
Bosch, F. X.
宫颈细胞学的准确性：在挪威三家医院中四名病理学家阅读的100张子宫颈抹片检查的诊断比较。
影响因子：
--
作者：
Sørbye SW;Suhrke P;Revå BW;Berland J;Maurseth RJ;Al-Shibli K
通讯作者：
Al-Shibli K