MicroRNAs in B cell development and malignancy.
MicroRNAs in B cell development and malignancy.
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DOI：
10.1186/1756-8722-5-7
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发表时间：
2012-03-08
影响因子：
28.5
通讯作者：
Rao DS
中科院分区：
文献类型：
--
作者：
Fernando TR;Rodriguez-Malave NI;Rao DS
MicroRNAs are small RNA molecules that regulate gene expression and play critical roles in B cell development and malignancy. miRNA expression is important globally, as B cell specific knockouts of Dicer show profound defects in B cell development; and is also critical at the level of specific miRNAs. In this review, we discuss miRNAs that are involved in normal B cell development in the bone marrow and during B cell activation and terminal differentiation in the periphery. Next, we turn to miRNAs that are dysregulated during diseases of B cells, including malignant diseases and autoimmunity. Further study of miRNAs and their targets will lead to a better understanding of B cell development, and should also lead to the development of novel therapeutic strategies against B cell diseases.
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影响因子：
5.4
作者：
Cameron, Jennifer E.;Yin, Qinyan;Flemington, Erik K.
通讯作者：
Flemington, Erik K.
DOI：
10.1038/nrrheum.2010.81
发表时间：
2010-07
期刊：
Nature reviews. Rheumatology
影响因子：
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作者：
通讯作者：
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DOI：
10.1126/science.1190809
发表时间：
2010-06-25
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
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影响因子：
32.4
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DOI：
10.1073/pnas.0602266103
发表时间：
2006-05-02
影响因子：
11.1
作者：
Costinean, S;Zanesi, N;Croce, CM
通讯作者：
Croce, CM