MDM2+/CDK4+/p53+ oral liposarcoma: case report and review of the literature.
MDM2+/CDK4+/p53+ oral liposarcoma: case report and review of the literature.
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MDM2 /CDK4 /p53 口腔脂肪肉瘤：病例报告和文献综述。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
J. Sauk
中科院分区：
文献类型：
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作者：
N. Nikitakis;M. Lopes;A. Pazoki;R. Ord;J. Sauk
尽管脂肪肉瘤是最常见的软组织肉瘤之一，但其发生在口腔的情况却非常罕见。据我们所知，英文文献中仅报道了 43 例起源于口腔组织的脂肪肉瘤病例。在本文中，我们报告了一例影响一名 28 岁男性面颊的高分化脂肪肉瘤病例，并回顾了口腔脂肪肉瘤文献。肿瘤的免疫组织化学分析显示 MDM2+/CDK4+/p53+ 免疫表型与源自身体其他部位的分化良好的脂肪肉瘤的免疫组织化学特征一致。对 MDM2（鼠双分钟 2 型人类同源物）、CDK4（细胞周期蛋白依赖性激酶 4）和 SAS（肉瘤扩增序列）基因的 DNA 水平进行定量聚合酶链反应分析，结果显示仅 SAS 基因扩增。强调了口腔脂肪肉瘤因其有时不明显的临床和显微镜特征而被误诊的可能性。仔细的脂肪肉瘤病理检查对于区分良性脂肪组织肿瘤和精确的组织学分类至关重要，两者都具有重要的预后意义。讨论了分子和细胞遗传学分析对于阐明脂肪肉瘤的发病机制和确定预后的可能意义。
Although liposarcoma is one of the most common soft tissue sarcomas, its location in the oral cavity is very rare. To our knowledge, only 43 cases of liposarcoma originating in the oral tissues have been reported in the English-language literature. In this article, we report a case of well-differentiated liposarcoma affecting the cheek of a 28-year-old man and review the oral liposarcoma literature. Immunohistochemical analysis of the tumor revealed an MDM2+/CDK4+/p53+ immunophenotype that is consistent with the immunohistochemical profile of well-differentiated liposarcoma originating in other areas of the body. Quantitative polymerase chain reaction analysis of the DNA levels of the MDM2 (human homologue of the murine double-minute type 2), CDK4 (cyclin-dependent kinase 4), and SAS (sarcoma amplified sequence), genes was performed, revealing only SAS gene amplification. The possibility of misdiagnosis of oral liposarcoma because of its sometimes inconspicuous clinical and microscopic features is emphasized. Careful pathologic examination of liposarcoma is essential for discrimination from benign adipose tissue neoplasms and for precise histologic classification, both of major prognostic significance. Possible implications of molecular and cytogenetic analysis for unraveling the pathogenesis and determining the prognosis of liposarcoma are discussed.
影响因子：
11.2
作者：
F. Leach;T. Tokino;T. Tokino;Paul A. Meltzer;M. Burrell;J. Oliner;Sharon Smith;D. Hill;D. Sidransky;K. Kinzler;B. Vogelstein
通讯作者：
F. Leach;T. Tokino;T. Tokino;Paul A. Meltzer;M. Burrell;J. Oliner;Sharon Smith;D. Hill;D. Sidransky;K. Kinzler;B. Vogelstein
影响因子：
8
作者：
S. A. Jankowski;D. Mitchell;Sharon Smith;J. Trent;P. Meltzer
通讯作者：
S. A. Jankowski;D. Mitchell;Sharon Smith;J. Trent;P. Meltzer