Environmental Toxicant Exposure and Hypertensive Disorders of Pregnancy: Recent Findings.
Environmental Toxicant Exposure and Hypertensive Disorders of Pregnancy: Recent Findings.
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DOI：
10.1007/s11906-018-0888-5
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发表时间：
2018-08-08
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
评估环境毒物与妊娠期高血压疾病之间关联的证据强度，基于动物和体外研究提出潜在的生物学机制，并强调未来研究的途径。有最有力的证据表明，铅、镉、有机氯农药和多环联苯等持久性化学品与先兆子痫之间存在联系，尽管在低暴露水平下有时无法检测到这种联系。双酚、邻苯二甲酸酯和有机磷酸酯的结果尚不确定。生物学途径可能包括氧化应激、表观遗传变化、内分泌干扰和异常胎盘血管形成。需要从孕前开始并延长产后进行额外的前瞻性流行病学研究，以评估环境暴露的生命过程轨迹以及女性的生殖和心血管健康。未来的研究还应考虑化学品之间的相互作用，并考虑非线性关联。这些结果证实了国际妇产科联合会、美国生殖医学会、美国儿科学会和内分泌学会的建议，即提供者建议他们的怀孕患者限制接触环境毒物。
To assess the strength of evidence for associations between environmental toxicants and hypertensive disorders of pregnancy, suggest potential biological mechanisms based on animal and in vitro studies, and highlight avenues for future research. Evidence is strongest for links between persistent chemicals, including lead, cadmium, organochlorine pesticides, and polycyclic biphenyls, and preeclampsia, although associations are sometimes not detectable at low-exposure levels. Results have been inconclusive for bisphenols, phthalates, and organophosphates. Biological pathways may include oxidative stress, epigenetic changes, endocrine disruption, and abnormal placental vascularization. Additional prospective epidemiologic studies beginning in the preconception period and extending postpartum are needed to assess the life course trajectory of environmental exposures and women’s reproductive and cardiovascular health. Future studies should also consider interactions between chemicals and consider nonlinear associations. These results confirm recommendations by the International Federation of Gynecology and Obstetrics, the American Society for Reproductive Medicine, the American Academy of Pediatrics, and the Endocrine Society that providers counsel their pregnant patients to limit exposure to environmental toxicants.
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DOI：
10.1016/j.fct.2016.06.023
发表时间：
2016-12
期刊：
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
影响因子：
--
作者：
Brooks SA;Martin E;Smeester L;Grace MR;Boggess K;Fry RC
通讯作者：
Fry RC
血液铅水平和先兆子痫之间的关系。
影响因子：
--
作者：
Bayat F;Akbari SA;Dabirioskoei A;Nasiri M;Mellati A
通讯作者：
Mellati A
影响因子：
10.4
作者：
Abhyankar LN;Jones MR;Guallar E;Navas-Acien A
通讯作者：
Navas-Acien A
影响因子：
6.1
作者：
Carmignani, M;Volpe, AR;Felaco, M
通讯作者：
Felaco, M
影响因子：
3.8
作者：
Benachour, Nora;Aris, Aziz
通讯作者：
Aris, Aziz