16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands.

16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands.
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DOI:
10.1111/iji.12028
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发表时间:
2013-02
影响因子:
2.2
通讯作者:
Middleton D
Middleton D
中科院分区:
医学4区
文献类型:
--
作者:
Hollenbach JA;Augusto DG;Alaez C;Bubnova L;Fae I;Fischer G;Gonzalez-Galarza FF;Gorodezky C;Karabon L;Kusnierczyk P;Noble J;Rickards O;Roberts C;Schaffer M;Shi L;Tavoularis S;Trachtenberg E;Yao Y;Middleton D

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在过去的15年中,已发表的报告描述了KIR基因含量的频率分布在全球120多个人群。然而,为查明区域和全球一级的总体变化模式而对这些数据进行总体审查的研究有限。在这里,我们总结了作为第15届和第16届国际组织相容性和免疫遗传学研讨会的一部分收集的105个全球人群的KIR基因含量数据,以及数据分析的初步结果。在该项目的四年期间,34个实验室提供了数据,包括HGDP-CEPH人群的数据。此外,将第15届IHIW的数据和提供给allelefrequencies.net(AFND)数据库的数据与当前研讨会数据集相结合
In the last fifteen years published reports have described KIR gene-content frequency distributions in more than 120 populations worldwide. However, there have been limited studies examining these data in aggregate in order to detect overall patterns of variation at regional and global levels. Here, we present a summary of the collection of KIR gene-content data for 105 worldwide populations collected as part of the 15th and 16th International Histocompatibility and Immunogenetics Workshops, and preliminary results for data analysis. The data were contributed by thirty-four laboratories during the four-year course of this project, including data for the HGDP-CEPH populations. Additionally, data from the 15th IHIW and data contributed to the allelefrequencies.net (AFND) database were combined with the current workshop dataset
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