The relation between auditory-nerve temporal responses and perceptual rate integration in cochlear implants.
The relation between auditory-nerve temporal responses and perceptual rate integration in cochlear implants.
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DOI：
10.1016/j.heares.2014.07.007
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发表时间：
2014-10
期刊：
影响因子：
2.8
通讯作者：
Goehring, Jenny L.
中科院分区：
文献类型：
--
作者：
Hughes, Michelle L.;Baudhuin, Jacquelyn L.;Goehring, Jenny L.
本研究的目的是研究不同频率电脉冲序列（“频率整合”）的听神经时间反应特性及其与心理物理阈值的关系。主要假设是，作为刺激速率的函数（振幅速率函数的斜率较浅），较好的速率积分（斜率较陡）将与较小的ECAP振幅衰减相关，这反映了更大比例的神经群对训练中的每个脉冲的同步贡献。获得23例人工耳蜗受者26耳的数据。电诱发复合动作电位（ECAP）的幅值被测量响应于一个脉冲序列中的21个脉冲：900、1200、1800、2400和3500 pps。心理物理阈值采用3间隔、强迫选择自适应程序，对与ECAP测量相同速率的300毫秒脉冲序列进行测量，形成速率积分函数。对于每个电极，将心理物理速率积分函数的斜率与以下ECAP测量值进行比较：(1)脉冲间平均标准化ECAP振幅与刺激速率（“适应”）的斜率，(2)脉冲序列间产生最大交替深度的速率，以及(3)交替模式停止的速率（随机速率）。结果显示，当数据跨受试者折叠时，速率积分函数的斜率与任何ECAP测量值之间没有显着关系。然而，小组数据显示，阈值和平均ECAP振幅都随着刺激率的增加而下降，受试者内部分析显示，心理物理阈值和整个脉冲序列的平均ECAP反应振幅之间存在显著的正相关。这些数据表明，ECAP的时间反应模式是复杂的，需要进一步的研究来更好地理解个体神经元的适应、去同步和放电概率对总体ECAP反应的相对贡献。
The purpose of this study was to examine auditory-nerve temporal response properties and their relation to psychophysical threshold for electrical pulse trains of varying rates (“rate integration”). The primary hypothesis was that better rate integration (steeper slope) would be correlated with smaller decrements in ECAP amplitude as a function of stimulation rate (shallower slope of the amplitude-rate function), reflecting a larger percentage of the neural population contributing more synchronously to each pulse in the train. Data were obtained for 26 ears in 23 cochlear-implant recipients. Electrically evoked compound action potential (ECAP) amplitudes were measured in response to each of 21 pulses in a pulse train for the following rates: 900, 1200, 1800, 2400, and 3500 pps. Psychophysical thresholds were obtained using a 3-interval, forced-choice adaptive procedure for 300-ms pulse trains of the same rates as used for the ECAP measures, which formed the rate-integration function. For each electrode, the slope of the psychophysical rate-integration function was compared to the following ECAP measures: (1) slope of the function comparing average normalized ECAP amplitude across pulses versus stimulation rate (“adaptation”), (2) the rate that produced the maximum alternation depth across the pulse train, and (3) rate at which the alternating pattern ceased (stochastic rate). Results showed no significant relations between the slope of the rate-integration function and any of the ECAP measures when data were collapsed across subjects. However, group data showed that both threshold and average ECAP amplitude decreased with increased stimulus rate, and within-subject analyses showed significant positive correlations between psychophysical thresholds and mean ECAP response amplitudes across the pulse train. These data suggest that ECAP temporal response patterns are complex and further study is required to better understand the relative contributions of adaptation, desynchronization, and firing probabilities of individual neurons that contribute to the aggregate ECAP response.
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影响因子：
1.6
作者：
Friesen, LM;Shannon, RV;Cruz, RJ
通讯作者：
Cruz, RJ
影响因子：
2.8
作者：
SHANNON, RV
通讯作者：
SHANNON, RV
影响因子：
2.8
作者：
Cartee, LA;van den Honert, C;Miller, RL
通讯作者：
Miller, RL
影响因子：
2.8
作者：
Matsuoka, AJ;Abbas, PJ;Miller, CA
通讯作者：
Miller, CA
DOI：
10.1007/s10162-007-0108-5
发表时间：
2008-03-01
影响因子：
2.4
作者：
Miller, Charles A.;Hu, Ning;Abbas, Paul J.
通讯作者：
Abbas, Paul J.