Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis.
Nutraceuticals: potential for chondroprotection and molecular targeting of osteoarthritis.
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DOI：
10.3390/ijms141123063
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发表时间：
2013-11-21
影响因子：
5.6
通讯作者：
Sun HB
中科院分区：
文献类型：
--
作者：
Leong DJ;Choudhury M;Hirsh DM;Hardin JA;Cobelli NJ;Sun HB
骨关节炎（OA）是一种退行性关节疾病，是导致成人残疾的主要原因。OA无法治愈，也没有有效的治疗方法可以阻止或减缓其进展。目前的药物治疗（如镇痛药）可能改善疼痛缓解，但不会改变OA疾病进展。长期服用这些药物会导致严重的不良反应。鉴于OA的性质，可能需要终身治疗以阻止或减缓其进展。因此，迫切需要OA疾病修饰疗法，其也改善症状并且在长期临床使用中是安全的。营养保健品-提供医疗或健康益处的食品或食品，包括预防和/或治疗疾病-不仅提供有利的安全性，而且可能对OA产生疾病和疾病修饰作用。47%的OA患者使用替代药物，包括营养保健品。本文综述了常用营养保健品的功效和作用机制，讨论了最近的实验和临床数据的影响，选择营养保健品，如植物黄酮类化合物，多酚类化合物，和生物素类化合物对OA，并强调其已知的分子作用和局限性，他们目前的使用。最后，我们将提出一种新的基于营养素的分子靶向策略，用于软骨保护和OA治疗。
Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. There is no cure for OA, and no effective treatments which arrest or slow its progression. Current pharmacologic treatments such as analgesics may improve pain relief but do not alter OA disease progression. Prolonged consumption of these drugs can result in severe adverse effects. Given the nature of OA, life-long treatment will likely be required to arrest or slow its progression. Consequently, there is an urgent need for OA disease-modifying therapies which also improve symptoms and are safe for clinical use over long periods of time. Nutraceuticals—food or food products that provide medical or health benefits, including the prevention and/or treatment of a disease—offer not only favorable safety profiles, but may exert disease- and symptom-modification effects in OA. Forty-seven percent of OA patients use alternative medications, including nutraceuticals. This review will overview the efficacy and mechanism of action of commonly used nutraceuticals, discuss recent experimental and clinical data on the effects of select nutraceuticals, such as phytoflavonoids, polyphenols, and bioflavonoids on OA, and highlight their known molecular actions and limitations of their current use. We will conclude with a proposed novel nutraceutical-based molecular targeting strategy for chondroprotection and OA treatment.
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DOI：
10.1124/jpet.103.059220
发表时间：
2004-02-01
影响因子：
3.5
作者：
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