Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells.

Boron nitride nanotubes are noncytotoxic and can be functionalized for interaction with proteins and cells.
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DOI:
10.1021/ja807334b
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发表时间:
2009-01-28
影响因子:
15
通讯作者:
Bertozzi CR
Bertozzi CR
中科院分区:
化学1区
文献类型:
--
作者:
Chen X;Wu P;Rousseas M;Okawa D;Gartner Z;Zettl A;Bertozzi CR

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我们报道了一项发现,氮化硼纳米管(BNNTs)是具有独特物理性质的碳纳米管的同分异构体,具有固有的非细胞毒性。此外,我们开发了一种仿生涂层策略,将bnnt与蛋白质和细胞结合。最后,我们发现bnnt可以将DNA低聚物传递到细胞内部,而没有明显的毒性。这项工作表明,bnnt在用作生物探针和生物材料方面可能优于碳纳米管。
We report the discovery that boron nitride nanotubes (BNNTs), isosteres of CNTs with unique physical properties, are inherently noncytotoxic. Furthermore, we developed a biomemetic coating strategy to interface BNNTs with proteins and cells. Finally, we showed that BNNTs can deliver DNA oligomers to the interior of cells with no apparent toxicity. This work suggests that BNNTs may be superior to CNTs for use as biological probes and in biomaterials.
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