Java project on periodontal diseases: serotype distribution of Aggregatibacter actinomycetemcomitans and serotype dynamics over an 8-year period.
Java project on periodontal diseases: serotype distribution of Aggregatibacter actinomycetemcomitans and serotype dynamics over an 8-year period.
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爪哇牙周病项目：8 年期间 Aggregatibacter actinomycetemcomitans 的血清型分布和血清型动态。
DOI：
10.1111/j.1600-051x.2008.01218.x
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发表时间：
2008
影响因子：
6.7
通讯作者：
A. V. van Winkelhoff
中科院分区：
文献类型：
--
作者：
W. A. van der Reijden;C. J. Bosch;U. van der Velden;A. V. van Winkelhoff
目的
在未经治疗的印度尼西亚受试者中，调查伴放线聚集杆菌的血清型分布和8年的稳定性。
材料和方法
临床牙周状况和A。在1994年和2002年，在印度尼西亚一个被剥夺牙科保健的茶园的107名受试者中建立了放线菌共生体。平均每例患者有3.6株分离株进行传代培养，并使用特异性PCR反应进行血清分型。
结果
1994年，主要血清型为B型（53.7%），而a型和c型分别占受试者的17.1%和14.6%。2002年，血清型a（7.5%）和B（30.2%）有所减少。血清型c和e的患病率分别从14.6%上升到35.8%和2.4%上升到9.4%。1994年发现12.2%的人有多种血清型，2002年为17%。在两个时间点均为阳性的24名受试者中，14名（58.3%）具有相同的血清型，而在10名受试者（41.7%）中发现不同的血清型。伴放线菌
结论
A.伴放线菌血清型在印度尼西亚年轻人中的分布从主要的血清型B转变为血清型B和C的更均等的流行。这种转变表明A.伴放线菌
OBJECTIVE
To investigate the serotype distribution and stability of Aggregatibacter actinomycetemcomitans over an 8-year period in untreated Indonesian subjects.
MATERIAL AND METHODS
Clinical periodontal status and the presence of A. actinomycetemcomitans were established in 1994 and 2002 in 107 subjects from an Indonesian tea estate deprived from dental care. On an average, 3.6 isolates per patient were subcultured and serotyped using specific PCR reactions.
RESULTS
In 1994, the predominant serotype was b (53.7%), whereas a and c occurred in 17.1% and 14.6% of the subjects, respectively. In 2002, a reduction in serotypes a (7.5%) and b (30.2%) occurred. Serotypes c and e increased in prevalence from 14.6% to 35.8% and 2.4% to 9.4%, respectively. Multiple serotypes were found in 12.2% in 1994 and 17% in 2002. From 24 subjects who were positive at both time points, 14 (58.3%) had the same serotype, whereas in 10 subjects (41.7%), a different serotype was found. Mean clinical attachment loss had increased from 0.74 mm in 1994 to 1.96 mm in 2002 but could not be related to subgingival presence of A. actinomycetemcomitans.
CONCLUSIONS
A. actinomycetemcomitans serotypes distribution in Indonesian young adults shifts from predominantly serotype b to a more equal prevalence of serotypes b and c. This shift suggests an opportunistic character of A. actinomycetemcomitans.
影响因子：
18.6
作者：
Haffajee, A D;Socransky, S S
通讯作者：
Socransky, S S