A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice.
A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and mice.
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DOI：
10.1038/s41467-022-35126-3
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发表时间：
2022-12-03
影响因子：
16.6
通讯作者：
Thornton, Emily E.
中科院分区：
文献类型：
--
作者：
Hackstein, Carl-Philipp;Costigan, Dana;Drexhage, Linnea;Pearson, Claire;Bullers, Samuel;Ilott, Nicholas;Akther, Hossain Delowar;Gu, Yisu;FitzPatrick, Michael E. B.;Harrison, Oliver J.;Garner, Lucy C.;Mann, Elizabeth H.;Pandey, Sumeet;Friedrich, Matthias;Provine, Nicholas M.;Uhlig, Holm H.;Marchi, Emanuele;Powrie, Fiona;Klenerman, Paul;Thornton, Emily E.
Interactions with commensal microbes shape host immunity on multiple levels and play a pivotal role in human health and disease. Tissue-dwelling, antigen-specific T cells are poised to respond to local insults, making their phenotype important in the relationship between host and microbes. Here we show that MHC-II restricted, commensal-reactive T cells in the colon of both humans and mice acquire transcriptional and functional characteristics associated with innate-like T cells. This cell population is abundant and conserved in the human and murine colon and endowed with polyfunctional effector properties spanning classic Th1- and Th17-cytokines, cytotoxic molecules, and regulators of epithelial homeostasis. T cells with this phenotype are increased in ulcerative colitis patients, and their presence aggravates pathology in dextran sodium sulphate-treated mice, pointing towards a pathogenic role in colitis. Our findings add to the expanding spectrum of innate-like immune cells positioned at the frontline of intestinal immune surveillance, capable of acting as sentinels of microbes and the local cytokine milieu. Interactions between the host immune response and the commensal microbiota play essential roles in health and disease. Here the authors identify a population of MHC class II, innate like, commensal reactive cells in the gut of mice and humans.
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DOI：
10.1084/jem.20092253
发表时间：
2010-06-07
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Feng T;Wang L;Schoeb TR;Elson CO;Cong Y
通讯作者：
Cong Y
DOI：
10.1126/science.aax6624
发表时间：
2019-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinides MG;Link VM;Tamoutounour S;Wong AC;Perez-Chaparro PJ;Han SJ;Chen YE;Li K;Farhat S;Weckel A;Krishnamurthy SR;Vujkovic-Cvijin I;Linehan JL;Bouladoux N;Merrill ED;Roy S;Cua DJ;Adams EJ;Bhandoola A;Scharschmidt TC;Aubé J;Fischbach MA;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
8.8
作者：
FitzPatrick MEB;Provine NM;Garner LC;Powell K;Amini A;Irwin SL;Ferry H;Ambrose T;Friend P;Vrakas G;Reddy S;Soilleux E;Klenerman P;Allan PJ
通讯作者：
Allan PJ
影响因子：
64.5
作者：
Chung H;Pamp SJ;Hill JA;Surana NK;Edelman SM;Troy EB;Reading NC;Villablanca EJ;Wang S;Mora JR;Umesaki Y;Mathis D;Benoist C;Relman DA;Kasper DL
通讯作者：
Kasper DL
影响因子：
16.6
作者：
Cano-Gamez, Eddie;Soskic, Blagoje;Trynka, Gosia
通讯作者：
Trynka, Gosia