Enabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater.

Enabling accurate and early detection of recently emerged SARS-CoV-2 variants of concern in wastewater.
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在废水中,可以准确和早期检测最近出现的SARS-COV-2变体。

DOI:
10.1038/s41467-023-38184-3
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发表时间:
2023-05-17
影响因子:
16.6
通讯作者:
Treangen TJ
Treangen TJ
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Sapoval N;Liu Y;Lou EG;Hopkins L;Ensor KB;Schneider R;Stadler LB;Treangen TJ

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随着临床检测的减少,废水监测可以对社区中出现的SARS-CoV-2关注点变体(VoCs)提供至关重要的监测。在本文中,我们提出了QuaID,一种新的基于准唯一突变的挥发性有机化合物检测生物信息学工具。QuaID的好处有三方面:(i)提供长达3周的VoC检测,(ii)准确的VoC检测(在模拟基准测试中精度为95%),以及(iii)利用所有突变签名(包括插入和删除)。Sapoval等人介绍了基于准唯一突变的SARS-CoV-2变异检测的生物信息学工具QuaID。QuaID利用所有突变,包括插入和缺失,并在变异传播的早期提供精确的检测。
As clinical testing declines, wastewater monitoring can provide crucial surveillance on the emergence of SARS-CoV-2 variant of concerns (VoCs) in communities. In this paper we present QuaID, a novel bioinformatics tool for VoC detection based on quasi-unique mutations. The benefits of QuaID are three-fold: (i) provides up to 3-week earlier VoC detection, (ii) accurate VoC detection (>95% precision on simulated benchmarks), and (iii) leverages all mutational signatures (including insertions & deletions). Sapoval et al. introduce QuaID, a bioinformatics tool for SARS-CoV-2 variant detection based on quasi-unique mutations. QuaID leverages all mutations, including insertions and deletions, and provides precise detection of variants early in their spread.
DOI: 10.1016/j.watres.2022.119306
发表时间: 2022-11-01
期刊: WATER RESEARCH
影响因子: 12.8
作者:
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