Immunologic dysfunction in scleroderma: evidence for increased mast cell releasability and HLA-DR positivity in the dermis.
Immunologic dysfunction in scleroderma: evidence for increased mast cell releasability and HLA-DR positivity in the dermis.
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硬皮病的免疫功能障碍：真皮中肥大细胞释放性增加和 HLA-DR 阳性的证据。
DOI：
10.1002/art.1780310514
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发表时间：
1988
影响因子：
--
通讯作者：
J. Steigerwald
中科院分区：
文献类型：
--
作者：
M. Pearson;J. Huff;R. Giorno;S. Panicheewa;H. Claman;J. Steigerwald
为了研究肥大细胞和细胞介导的免疫在硬皮病发病机制中的作用，我们研究了用化合物48/80（肥大细胞组胺的解放者）进行皮肤试验后的轮状大小，结果表明，在与受累皮肤相邻的正常皮肤中，肥大细胞的释放性增加。HLA-DR免疫荧光染色显示，来自硬皮病患者的13个受累皮肤活检标本中有12个皮肤呈阳性，13个未受累皮肤活检标本中有9个皮肤呈阳性，相比之下，10个对照组中只有1个皮肤呈阳性。免疫过氧化物酶染色显示，DR阳性多见于成纤维细胞样细胞。这些发现进一步支持了硬皮病中免疫功能障碍的概念。
To investigate the role of mast cells and cell-mediated immunity in the pathogenesis of scleroderma, we studied wheal size after skin testing with compound 48/80, a liberator of mast cell histamine, and demonstrated increased mast cell releasability in skin that appeared normal, adjacent to involved skin. Immunofluorescent staining for HLA-DR showed dermal positivity in 12 of 13 involved- and 9 of 13 uninvolved-skin biopsy specimens from scleroderma patients, compared with only 1 of 10 controls. By immunoperoxidase staining, most of the DR positivity was found in fibroblast-like cells. These findings further support the notion of immunologic dysfunction in scleroderma.
影响因子：
--
作者：
ROUMM, AD;WHITESIDE, TL;RODNAN, GP
通讯作者：
RODNAN, GP
进行性系统性硬化症（PSS，硬皮病）患者 T 淋巴细胞亚群异常。
DOI：
--
发表时间：
1981
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Inoshita,T;Whiteside,TL;Rodnan,GP;Taylor,FH
通讯作者：
Taylor,FH