A comparison of breast density measures between mothers and adolescent daughters.
A comparison of breast density measures between mothers and adolescent daughters.
复制标题
比较母亲与青少年女儿之间的乳房密度度量。
DOI：
10.1186/1471-2407-11-330
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发表时间：
2011-08-02
期刊：
影响因子：
3.8
通讯作者：
Novotny R
中科院分区：
文献类型：
--
作者：
Maskarinec G;Morimoto Y;Daida Y;Shepherd J;Novotny R
基于乳房密度作为乳腺癌风险预测因子的重要性，我们使用双能 X 射线吸收测定法 (DXA) 检查了母亲和女儿乳房测量值的遗传成分。我们通过 Kaiser Permanente Hawaii 招募了 101 名 30 岁以上的母亲及其 10-16 岁的女儿。使用 DXA 系统在研究模式下对两个乳房进行扫描，并进行校准以区分纤维腺体和脂肪乳腺组织。我们计算了母亲和女儿之间乳房体积、绝对纤维腺体体积 (FGV) 和 %FGV 的相关系数，并进行了多元线性回归以包含相关协变量。女儿的乳房体积和绝对 FGV 低于母亲，并且与全身脂肪百分比和 Tanner 乳房阶段呈正相关。相比之下，女儿的 %FGV 高于母亲，并且与全身脂肪百分比呈负相关。尽管母亲和女儿之间未经调整的相关性在乳房体积和绝对 FGV 方面具有显着性（r = 0.28，p < 0.01），但针对人口变量、Tanner 阶段和全身脂肪百分比进行调整的模型表明，仅在较成熟的女孩（Tanner 阶段 4 和 5）中存在显着相关性。母亲和女儿的 %FGV 之间没有显着相关性。这些结果表明，乳房体积和致密组织数量的遗传力在青春期是可以测量的，但乳房密度百分比显示当时母亲和女儿之间没有关系。对青春期和年轻女性乳腺组织成分的进一步研究可能会增强对以后生活中患乳腺癌风险的了解。
Based on the importance of breast density as a predictor of breast cancer risk, we examined the heritable component of breast measures in mothers and daughters using Dual Energy X-ray Absorptiometry (DXA). We recruited 101 mothers ≥30 years and their daughters aged 10-16 years through Kaiser Permanente Hawaii. Scans of both breasts were taken using a DXA system in research mode, calibrated to distinguish fibroglandular and fatty breast tissue. We calculated correlation coefficients between mothers and daughters for breast volume, absolute fibroglandular volume (FGV), and %FGV and performed multiple linear regression to include relevant covariates. Breast volume and absolute FGV in daughters were lower than in mothers and were positively associated with % total body fat and Tanner breast stage. In contrast, %FGV in daughters was higher than in mothers and was inversely associated with % total body fat. Although unadjusted correlations between mothers and daughters were significant for breast volume and absolute FGV (r = 0.28 and p < 0.01 for both), models adjusted for demographic variables, Tanner stage, and % total body fat indicated significant associations only among the more mature girls (Tanner stages 4&5). There was no significant association between %FGV of mothers and daughters. These results indicate that the heritability of breast volume and amount of dense tissue is measurable in adolescence, but percent breast density shows no relation between mothers and daughters at that time. Further study of breast tissue composition during adolescence and in young women may enhance understanding of breast cancer risk later in life.
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影响因子：
2.3
作者：
Crest, Anthony B.;Aiello, Erin J.;Buist, Diana S. M.
通讯作者：
Buist, Diana S. M.
影响因子：
3.8
作者：
Maskarinec, Gertraud;Pagano, Ian;Gram, Inger Torhild
通讯作者：
Gram, Inger Torhild
影响因子：
3.1
作者：
Ruder EH;Dorgan JF;Kranz S;Kris-Etherton PM;Hartman TJ
通讯作者：
Hartman TJ
影响因子：
3.8
作者：
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通讯作者：
Silva, ID
影响因子：
2.5
作者：
Howard, BA;Gusterson, BA
通讯作者：
Gusterson, BA