Influence of blood flow on cardiac development.
Influence of blood flow on cardiac development.
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DOI：
10.1016/j.pbiomolbio.2018.05.005
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发表时间：
2018-09
影响因子：
3.8
通讯作者：
Rugonyi S
中科院分区：
文献类型：
--
作者：
Courchaine K;Rykiel G;Rugonyi S
血流动力学在心血管发展中的作用尚不清楚。事实上，考虑到遗传、分子、机械和环境因素在起作用，如果是这样的话，那将是非常了不起的。然而，先天性心脏缺陷约占人类出生总数的1 / 100，并且大量研究指出血液动力学是心血管形态发生的一个因素，这不是一个我们可以保持黑暗的领域。这篇综述旨在为研究发展中的心血管系统的生物力学的重要性提出案例。这是通过i)说明一些涉及心脏发育的高度复杂过程的基础，并讨论已知的血流动力学对这些过程的影响来实现的；Ii)证明改变的血流动力学环境如何有可能带来形态异常，引用多种动物模型的研究，采用各种摄动方法；Iii)提供广泛使用的技术创新的例子，这些技术创新可以精确测量胚胎的血流动力学参数；Iv)详细介绍了禽类胚胎的研究结果，这些结果指出了早期发育过程中各种血流动力学操作与成熟心脏中表型缺陷发生率之间令人兴奋的相关性；最后，v)强调揭示不利条件下心血管形成和重塑的特定生物力学途径与人类患者潜在治疗的相关性。揭示血流动力学对心脏发育的贡献，并认识到它们在心脏畸形表型发生中经常被忽视的作用的时机已经成熟。
The role of hemodynamics in cardiovascular development is not well understood. Indeed, it would be remarkable if it were, given the dauntingly complex array of intricately synchronized genetic, molecular, mechanical, and environmental factors at play. However, with congenital heart defects affecting around 1 in 100 human births, and numerous studies pointing to hemodynamics as a factor in cardiovascular morphogenesis, this is not an area in which we can afford to remain in the dark. This review seeks to present the case for the importance of research into the biomechanics of the developing cardiovascular system. This is accomplished by i) illustrating the basics of some of the highly complex processes involved in heart development, and discussing the known influence of hemodynamics on those processes; ii) demonstrating how altered hemodynamic environments have the potential to bring about morphological anomalies, citing studies in multiple animal models with a variety of perturbation methods; iii) providing examples of widely used technological innovations which allow for accurate measurement of hemodynamic parameters in embryos; iv) detailing the results of studies in avian embryos which point to exciting correlations between various hemodynamic manipulations in early development and phenotypic defect incidence in mature hearts; and finally, v) stressing the relevance of uncovering specific biomechanical pathways involved in cardiovascular formation and remodeling under adverse conditions to the potential treatment of human patients. The time is ripe to unravel the contributions of hemodynamics to cardiac development, and to recognize their frequently neglected role in the occurrence of heart malformation phenotypes.
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影响因子：
11.8
作者：
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