Blood-brain barrier pathophysiology in traumatic brain injury.
Blood-brain barrier pathophysiology in traumatic brain injury.
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DOI：
10.1007/s12975-011-0125-x
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发表时间：
2011-12
影响因子：
6.9
通讯作者：
Szmydynger-Chodobska J
中科院分区：
文献类型：
--
作者：
Chodobski A;Zink BJ;Szmydynger-Chodobska J
血脑屏障（BBB）是由脑血管内皮细胞紧密连接而成，但其正常功能也依赖于脑内皮细胞与邻近胶质细胞之间的旁分泌相互作用。越来越多的共识是，脑损伤，无论是缺血性、出血性还是创伤性，都会导致BBB功能障碍。损伤后观察到的BBB功能的变化被认为有助于神经组织的损失，并影响对神经保护药物的反应。新的发现表明，考虑整个胶质血管单位，而不是单独的血脑屏障，将扩大我们对创伤性脑损伤（TBI）的细胞和分子反应的理解。本文综述了TBI时血脑屏障（BBB）的破坏、血液因素在影响胶质血管单位功能中的作用、血脑屏障通透性的变化和创伤后水肿的形成，以及与TBI相关的可能导致创伤后血脑屏障功能障碍的主要病理生理因素。还将描述神经炎症的关键作用和损伤对血脑屏障运输机制的可能影响。最后，通过损伤后恢复正常的血脑屏障功能和/或利用脑血管内皮细胞产生神经营养生长因子，血脑屏障作为治疗干预的靶点的潜在作用将被讨论。
The blood-brain barrier (BBB) is formed by tightly connected cerebrovascular endothelial cells, but its normal function also depends on paracrine interactions between the brain endothelium and closely located glia. There is a growing consensus that brain injury, whether it is ischemic, hemorrhagic, or traumatic, leads to dysfunction of the BBB. Changes in BBB function observed after injury are thought to contribute to the loss of neural tissue and to affect the response to neuroprotective drugs. New discoveries suggest that considering the entire gliovascular unit, rather than the BBB alone, will expand our understanding of the cellular and molecular responses to traumatic brain injury (TBI). This review will address the BBB breakdown in TBI, the role of blood-borne factors in affecting the function of the gliovascular unit, changes in BBB permeability and post-traumatic edema formation, and the major pathophysiological factors associated with TBI that may contribute to post-traumatic dysfunction of the BBB. The key role of neuroinflammation and the possible effect of injury on transport mechanisms at the BBB will also be described. Finally, the potential role of the BBB as a target for therapeutic intervention through restoration of normal BBB function after injury and/or by harnessing the cerebrovascular endothelium to produce neurotrophic growth factors will be discussed.
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影响因子：
1.9
作者：
Balabanov, R;Goldman, H;Dore-Duffy, P
通讯作者：
Dore-Duffy, P
DOI：
10.1073/pnas.0808698106
发表时间：
2009-02-10
影响因子：
11.1
作者：
Argaw, Azeb Tadesse;Gurfein, Blake T.;John, Gareth R.
通讯作者：
John, Gareth R.
DOI：
10.1097/00004647-200106000-00006
发表时间：
2001-06-01
影响因子：
6.3
作者：
Beech, JS;Reckless, J;Menon, DK
通讯作者：
Menon, DK
影响因子：
2.9
作者：
Armao, D;Kornfeld, M;Rosenberg, GA
通讯作者：
Rosenberg, GA
影响因子：
5.5
作者：
Carlos, TM;Clark, RSB;Kochanekt, PM
通讯作者：
Kochanekt, PM