Interplay between the gut microbiota and immune responses of ayu (Plecoglossus altivelis) during Vibrio anguillarum infection
Interplay between the gut microbiota and immune responses of ayu (Plecoglossus altivelis) during Vibrio anguillarum infection
复制标题
鳗弧菌感染期间肠道菌群与香鱼（Plecoglossus altivelis）免疫反应之间的相互作用
DOI：
10.1016/j.fsi.2017.07.054
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发表时间：
2017-09
影响因子：
4.7
通讯作者：
Chen J
中科院分区：
文献类型：
--
作者：
Nie L;Zhou QJ;Qiao Y;Chen J
肠道菌群在抵御病原体入侵方面起着重要作用。然而，肠道菌群对致病性感染的反应机制和程度尚不清楚。本研究研究了阿育鱼暴露于鳗弧菌后肠道细菌群落和免疫反应。v的继承安圭拉感染的证据是免疫基因表达和细菌负荷增加，这反过来改变了肠道细菌群落的组成和预测功能。在对照组中，肠道细菌多样性和均匀性的动态变化暂时稳定，但在感染组中，特别是在感染后期，肠道细菌多样性和均匀性的动态变化有所减少。肠道菌群的变化与TNF-α (P= 0.019)和IL-1 β (P= 0.013)的表达水平显著相关。某些肠道细菌分类群的特征表明v。anguillaruminfection。与健康对照组相比，感染v病毒的ayu。鳗鲡的肠道细菌在物种间的相互作用不那么复杂、联系更少、合作程度更低，这与关键物种的重大转变相吻合。这些发现暗示v。鳗鲡感染严重破坏了ayu肠道细菌群落的组成和种间相互作用，从而改变肠道微生物介导的功能并诱导宿主免疫反应。本研究从生态学的角度对肠道微生物群与宿主对病原体感染的免疫反应之间的相互作用进行了综合综述。
Gut microbiota plays fundamental roles in protection against pathogen invasion. However, the mechanism and extent of responses of gut microbiota to pathogenic infection are poorly understood. This study investigated the gut bacterial communities and immune responses of ayu (Plecoglossus altivelis) upon exposure to Vibrio anguillarum. The succession ofV. anguillaruminfection was evidenced by increased expression of immune genes and bacterial loads in ayu tissues, which in turn altered the composition and predicted functions of gut bacterial community. The dynamics of gut bacterial diversity and evenness were temporally stable in control ayu but were reduced in infected subjects, particularly at the late stages of infection. Variations in the gut microbiota were significantly associated with the expression levels of TNF-α (P= 0.019) and IL-1 β (P= 0.013). The profiles of certain gut bacterial taxa were indicative ofV. anguillaruminfection. Compared with healthy controls, the ayu infected withV. anguillarumpossessed less complex, fewer connected, and lower cooperative gut bacterial interspecies interaction, coinciding with significant shifts in keystone species. These findings imply thatV. anguillaruminfection substantially disrupted the compositions and interspecies interaction of ayu gut bacterial community, thereby altering gut microbial-mediated functions and inducing host immune responses. This study provides an integrated overview on the interaction between the gut microbiota and host immune responses to pathogen infection from an ecological perspective.
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影响因子：
12.2
作者：
Reeves, Angela E.;Theriot, Casey M.;Young, Vincent B.
通讯作者：
Young, Vincent B.
影响因子：
6.4
作者：
Shade A;Jones SE;Caporaso JG;Handelsman J;Knight R;Fierer N;Gilbert JA
通讯作者：
Gilbert JA
影响因子：
5.2
作者：
Petton B;Bruto M;James A;Labreuche Y;Alunno-Bruscia M;Le Roux F
通讯作者：
Le Roux F
影响因子：
82.9
作者：
通讯作者：
--
DOI：
10.1073/pnas.1107857108
发表时间：
2011-10-18
影响因子：
11.1
作者：
Thiennimitr, Parameth;Winter, Sebastian E.;Baeumler, Andreas J.
通讯作者：
Baeumler, Andreas J.