Intention tremor and deficits of sensory feedback control in multiple sclerosis: a pilot study.
Intention tremor and deficits of sensory feedback control in multiple sclerosis: a pilot study.
复制标题
DOI：
10.1186/1743-0003-11-170
复制
发表时间：
2014-12-19
影响因子：
5.1
通讯作者：
Beardsley SA
中科院分区：
文献类型：
--
作者：
Heenan M;Scheidt RA;Woo D;Beardsley SA
意向震颤和心律失常是多发性硬化(MS)患者上肢功能障碍的主要原因。由于对与MS相关的分布式多灶性病变如何影响大脑中的感觉运动控制的了解不足，阻碍了减少震颤和运动障碍的有效治疗方法的开发。在这里，我们描述了一种系统水平的方法来描述感觉运动控制的特征，并使用该方法来研究MS对感觉和运动过程的不同影响。8名患有多发性硬化症的受试者和8名年龄和性别匹配的健康对照组受试者进行了视觉引导的肘部屈曲/伸展任务，以表征包括三条感觉反馈路径的感觉反馈控制模型(一条用于视觉，另一条用于本体感觉，第三条提供对行为的感觉后果的内部预测)。该模型允许我们描述导致每个多发性硬化症受试者震颤的感觉反馈控制的损害。从多发性硬化症受试者的表现得出的模型在两个方面与对照受试者得到的模型不同。首先，患有多发性硬化症的受试者表现出明显的视觉反馈延迟，这种延迟没有被内部适应机制补偿；延迟最长的个体的稳定表现与对照受试者的表现差异最大。其次，患有多发性硬化症的受试者对手臂动力的错误估计与震颤功率有关。受试者特定的模型准确地预测了神经学上完整的对照组受试者在伸展和保持任务中的运动学表现，而多发性硬化症患者的模拟表现比实际受试者的反应具有更短的运动间隔和更大的终点误差。模拟和实际性能之间的这种差异与移动速度和终点精度的战略补偿权衡是一致的。我们的结果表明，震颤和节律困难可能是由于大脑调整感觉反馈机制以补偿视觉信息处理时间增加的能力受到限制，以及手臂动力学内部估计的补偿性适应错误所致。本文的在线版本(DOI：10.1186/1743000311-170)包含补充材料，授权用户可以使用。
Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor control in the brain. Here we describe a systems-level approach to characterizing sensorimotor control and use this approach to examine how sensory and motor processes are differentially impacted by MS. Eight subjects with MS and eight age- and gender-matched healthy control subjects performed visually-guided flexion/extension tasks about the elbow to characterize a sensory feedback control model that includes three sensory feedback pathways (one for vision, another for proprioception and a third providing an internal prediction of the sensory consequences of action). The model allows us to characterize impairments in sensory feedback control that contributed to each MS subject’s tremor. Models derived from MS subject performance differed from those obtained for control subjects in two ways. First, subjects with MS exhibited markedly increased visual feedback delays, which were uncompensated by internal adaptive mechanisms; stabilization performance in individuals with the longest delays differed most from control subject performance. Second, subjects with MS exhibited misestimates of arm dynamics in a way that was correlated with tremor power. Subject-specific models accurately predicted kinematic performance in a reach and hold task for neurologically-intact control subjects while simulated performance of MS patients had shorter movement intervals and larger endpoint errors than actual subject responses. This difference between simulated and actual performance is consistent with a strategic compensatory trade-off of movement speed for endpoint accuracy. Our results suggest that tremor and dysmetria may be caused by limitations in the brain’s ability to adapt sensory feedback mechanisms to compensate for increases in visual information processing time, as well as by errors in compensatory adaptations of internal estimates of arm dynamics. The online version of this article (doi:10.1186/1743-0003-11-170) contains supplementary material, which is available to authorized users.
登录
查看更多内容
影响因子：
2.5
作者：
Jones, KE;Hamilton, AFD;Wolpert, DM
通讯作者：
Wolpert, DM
影响因子：
11
作者：
Alusi, SH;Worthington, J;Bain, PG
通讯作者：
Bain, PG
DOI：
10.1109/tnsre.2012.2187462
发表时间：
2012-05-01
影响因子：
4.9
作者：
Carpinella, Ilaria;Cattaneo, Davide;Ferrarin, Maurizio
通讯作者：
Ferrarin, Maurizio
DOI：
10.1191/1352458503ms949oa
发表时间：
2003-01-01
期刊：
MULTIPLE SCLEROSIS
影响因子：
--
作者：
Feys, P;Helsen, WF;Ketelaer, P
通讯作者：
Ketelaer, P
影响因子：
1.7
作者：
Feys, P;Maes, F;Liu, XG
通讯作者：
Liu, XG