Reviewing and reconsidering invasion assays in head and neck cancer.
Reviewing and reconsidering invasion assays in head and neck cancer.
复制标题
DOI：
10.1016/j.oraloncology.2014.09.010
复制
发表时间：
2014-12
期刊：
影响因子：
4.8
通讯作者：
D'Silva, Nisha J.
中科院分区：
文献类型：
--
作者：
Inglehart, Ronald C.;Scanlon, Christina S.;D'Silva, Nisha J.
Head and neck squamous cell carcinomas (HNSCC) are malignant tumors that arise from the surface epithelium of the oral cavity, oropharynx and larynx, primarily due to exposure to chemical carcinogens or the human papilloma virus. Due to their location, dental practitioners are well-positioned to detect the lesions. Deadlier than lymphoma or melanoma, HNSCC is incompletely understood. For these reasons, dental practitioners and researchers are focused on understanding HNSCC and the processes driving it. One of these critical processes is invasion, the degradation of the basement membrane by HNSCC cells with subsequent movement into the underlying connective tissue, blood vessels or nerves. Cancer cells metastasize to distant sites via the blood vessels, lymphatics and nerves. Metastasis is associated with poor survival. Since invasion is essential for development and metastasis of HNSCC, it is essential to understand the mechanism(s) driving this process. Elucidation of the mechanisms involved will facilitate the development of targeted treatment, thereby accelerating development of precision/ personalized medicine to treat HNSCC. Robust in vitro and in vivo assays are required to investigate the mechanistic basis of invasion. This review will focus on in vitro and in vivo assays used to study invasion in HNSCC, with special emphasis on some of the latest assays to study HNSCC.
登录
查看更多内容
DOI：
10.1083/jcb.200802081
发表时间：
2008-06-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fackler OT;Grosse R
通讯作者：
Grosse R
DOI：
10.1038/jid.2010.106
发表时间：
2010-09
期刊：
The Journal of investigative dermatology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.5
作者：
Hamilton, Nicholas
通讯作者：
Hamilton, Nicholas
影响因子：
3.3
作者：
Czeminski, Rakefet;Amornphimoltham, Panomwat;Gutkind, J. Silvio
通讯作者：
Gutkind, J. Silvio
DOI：
10.1007/978-1-60761-380-0_24
发表时间：
2010-01-01
期刊：
EPIDERMAL CELLS: METHODS AND PROTOCOLS, SECOND EDITION
影响因子：
--
作者：
Egles, Christophe;Garlick, Jonathan A.;Shamis, Yulia
通讯作者：
Shamis, Yulia