Headache and migraine in mitochondrial disease and its impact on life-results from a cross-sectional, questionnaire-based study.
Headache and migraine in mitochondrial disease and its impact on life-results from a cross-sectional, questionnaire-based study.
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DOI：
10.1007/s13760-021-01630-4
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发表时间：
2021-10
影响因子：
2.7
通讯作者：
Kraya T
中科院分区：
文献类型：
--
作者：
Burow P;Meyer A;Naegel S;Watzke S;Zierz S;Kraya T
头痛是线粒体疾病患者的常见病。先前的研究指出，这些患者的头痛患病率高于一般人群。由于线粒体疾病经常表现出各种其他症状，问题就出现了，头痛的存在对日常生活的影响到底有多大。我们对61例主要由CPEO表型组成的线粒体疾病患者进行了横断面、基于问卷的研究调查。使用标准化问卷检查头痛，并根据ICHD-2进行分类。采用头痛影响测试-6 （HIT-6）评估头痛相关残疾。此外，使用医院焦虑和抑郁量表（HADS）检查抑郁和焦虑，并使用短期健康调查（SF-12）调查与健康相关的生活质量。43/61（70.5%）的患者报告头痛。61例患者中有35例（57.4%）为紧张性头痛（TTH）， 26例（42.6%）为偏头痛。报告头痛的患者HIT-6评分明显高于没有报告头痛的患者（平均：54.47比38.47,p < 0.001）。偏头痛患者的HIT-6评分明显高于紧张性头痛患者（平均：62.13比46.18,p < 0.001）。在HADS评分和SF-12中，头痛的发生没有显著影响。这项研究证实了先前报道的在一大批确诊线粒体疾病的患者中经常发生头痛。偏头痛对日常生活的影响最大，这似乎与抑郁和焦虑无关。因此，我们得出结论，偏头痛可能是线粒体疾病患者疾病负担的重要因素。
Headache is frequent in patients with mitochondrial disorders. Previous studies point to a higher prevalence of headache in these patients than in the general population. As mitochondrial disorders often present a variety of other symptoms, the question arises how much the presence of headache really influences daily life. We performed a cross-sectional, questionnaire-based study investigation with 61 patients with a genetically proved mitochondrial disease mainly composed of CPEO phenotype. Headache was examined using a standardized questionnaire, and classified according to ICHD-2. Headache-related disability was evaluated by the Headache-Impact-Test-6 (HIT-6). Additionally, depression and anxiety were examined using the Hospital Anxiety and Depression Scale (HADS) and Short-Form-Health Survey (SF-12) was used to investigate the health-related quality of life. Headache was reported by 43/61 (70.5%) of the patients. 35/61 patients (57.4%) described a Tension-type headache (TTH) and 26 patients (42.6%) a migraine. Patients reporting headache had a significantly higher HIT-6 score than those without (mean: 54.47 vs. 38.47, p < 0.001). The HIT-6 score was significantly higher in patients reporting a migraine compared to those with a tension-type headache (mean: 62.13 vs. 46.18, p < 0.001). In the HADS score and in the SF-12 were not significantly influenced by the occurrence of headache. This study confirms the previously reported frequent occurrence of headache in a large cohort of patients with a confirmed mitochondrial disease. Migraine had the greatest impact on daily living, which appeared not to be confounded by depression and anxiety. Thus, we conclude that Migraine may be a substantial contributor for burden of disease in patients with mitochondrial diseases.
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与成年线粒体疾病有关的核和线粒体DNA突变的患病率。
影响因子：
11.2
作者：
Gorman GS;Schaefer AM;Ng Y;Gomez N;Blakely EL;Alston CL;Feeney C;Horvath R;Yu-Wai-Man P;Chinnery PF;Taylor RW;Turnbull DM;McFarland R
通讯作者：
McFarland R
影响因子：
4.9
作者：
Vollono, Catello;Primiano, Guido;Servidei, Serenella
通讯作者：
Servidei, Serenella
影响因子：
3
作者：
Pfeffer, Gerald;Sirrs, Sandra;Mezei, Michelle M.
通讯作者：
Mezei, Michelle M.
影响因子：
7.4
作者：
Yoon, M-S;Katsarava, Z.;Obermann, M.;Fritsche, G.;Oezyurt, M.;Kaesewinkel, K.;Katsarova, A.;Santowski, I.;Diener, H.;Moebus, S.
通讯作者：
Moebus, S.
DOI：
10.1186/s10194-016-0649-2
发表时间：
2016
期刊：
The journal of headache and pain
影响因子：
--
作者：
Lampl C;Thomas H;Tassorelli C;Katsarava Z;Laínez JM;Lantéri-Minet M;Rastenyte D;Ruiz de la Torre E;Stovner LJ;Andrée C;Steiner TJ
通讯作者：
Steiner TJ