SDF-1 axis and myocardial repair.
SDF-1 axis and myocardial repair.
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SDF-1 轴和心肌修复。
DOI：
10.1152/ajpheart.00876.2010
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Rota,Marcello
中科院分区：
文献类型：
--
作者：
Rota,Marcello
当细胞丢失或心肌稳态破坏时，心脏维持血液动力学需求的能力受到极大挑战。使用干细胞或祖细胞的细胞疗法是恢复失去的心肌和使心室功能正常化的有希望的选择。最初的临床试验已经证明了这种治疗方法的可行性和安全性，并表明对患病心脏有潜在益处（2，3，29 11）。虽然已经鉴定了具有心源性潜力的各种细胞类型，但在细胞移植的背景下需要改进和优化几个方面，以成功地促进细胞保留、存活、植入并最终促进心肌再生。33心脏的再生能力有限，不足以在缺血发作后替换坏死组织（6）。然而，这些不良事件35触发祖细胞向损伤部位的募集（4），表明在缺氧期间激活的归巢信号36可被利用以将移植细胞靶向损伤的心肌。在缺血损伤后形成的分子中，基质-38细胞衍生因子-1（SDF-1）瞬时上调，并通过刺激这些原始细胞中的CXCR 4受体作为干细胞归巢剂（1，7，13）。因此，40 SDF-1/CXCR 4轴可能为细胞治疗提供潜在优势。41
The ability of the heart to sustain hemodynamic demands is greatly challenged when 25 cell loss or disruption of myocardial homeostasis occurs. Cell therapy using stem or 26 progenitor cells is a promising option to restore the lost myocardium and normalize 27 ventricular function. Initial, clinical trials have documented the feasibility and safety of 28 this therapeutic approach with indication of potential benefit for the diseased heart (2, 3, 29 11). While various cell types with cardiogenic potential have been identified, several 30 aspects need to be refined and optimized in the setting of cell transplantation to 31 successfully promote cell retention, survival, engraftment and, ultimately, myocardial 32 regeneration. 33The heart presents a limited regenerative capacity, which is inadequate to 34 replace the necrotic tissue after ischemic episodes (6). However, these adverse events 35 trigger the recruitment of progenitor cells to the site of injury (4), indicating that homing 36 signals activated during hypoxia may be exploited to target transplanted cells to the 37 damaged myocardium. Among the molecules formed after ischemic insults, stromal-38 cell-derived factor-1 (SDF-1) is transiently upregulated and acts as a stem cell homing 39 agent by stimulating the CXCR4 receptor in these primitive cells (1, 7, 13). Thus, the 40 SDF-1/CXCR4 axis may offer potential advantages for cell treatment. 41
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影响因子：
24
作者：
Hare, Joshua M.;Traverse, Jay H.;Henry, Timothy D.;Dib, Nabil;Strumpf, Robert K.;Schulman, Steven P.;Gerstenblith, Gary;DeMaria, Anthony N.;Denktas, Ali E.;Gammon, Roger S.;Hermiller, James B., Jr.;Reisman, Mark A.;Schaer, Gary L.;Sherman, Warren
通讯作者：
Sherman, Warren
DOI：
10.1152/ajpheart.00592.2010
发表时间：
2010-11-01
影响因子：
4.8
作者：
Zhang, Dongsheng;Huang, Wei;Wang, Yigang
通讯作者：
Wang, Yigang
影响因子：
5
作者：
Zhang, Dongsheng;Fan, Guo-Chang;Wang, Yigang
通讯作者：
Wang, Yigang
影响因子：
15.9
作者：
Jackson, KA;Majka, SM;Goodell, MA
通讯作者：
Goodell, MA
影响因子：
82.9
作者：
Miyahara, Y;Nagaya, N;Mori, H
通讯作者：
Mori, H