The moonlighting enzyme CD13: old and new functions to target.
The moonlighting enzyme CD13: old and new functions to target.
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DOI：
10.1016/j.molmed.2008.06.003
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发表时间：
2008-08
影响因子：
13.6
通讯作者：
Mina-Osorio P
中科院分区：
文献类型：
--
作者：
Mina-Osorio P
氨肽酶N（CD13）是一种广泛表达的胞外酶，其功能并不总是依赖于其酶活性：这是一个被忽视的方面。在过去的几年中，已经开发了许多CD13靶向工具。其中一些已经在进行临床试验，还有一些关于其他药物在疾病动物模型中的有效性的报告。然而，它们的疗效可能会被其对CD13未识别功能的影响所掩盖，从而导致意外的并发症。本综述的目的是（i）讨论归因于CD13的各种功能及其背后的可能机制，（ii）考虑一些需要回答的问题，以更好地理解这些功能的生物学相关性，更精确地解释其操作后获得的结果，并更合理地设计CD13靶向药物。
Aminopeptidase N (CD13) is a widely expressed ectoenzyme with functions that do not always depend on its enzymatic activity: an aspect that has been overlooked. Numerous CD13-targeting tools have been developed in the last few years. Several of them are already undergoing clinical trials, and there are promising reports on the effectiveness of others in animal models of disease. However, their efficacy might be obscured by their effects on unrecognized functions of CD13, resulting in unexpected complications. The purpose of this review is (i) to discuss the various functions ascribed to CD13 and the possible mechanisms behind them and (ii) to consider some of the questions that need to be answered to achieve a better understanding of the biological relevance of these functions, a more precise interpretation of the results obtained after their manipulation and a more rational design of CD13-targeting agents.
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DOI：
10.1073/pnas.0606167103
发表时间：
2006-09-05
影响因子：
11.1
作者：
Addlagatta, Anthony;Gay, Leslie;Matthews, Brian W.
通讯作者：
Matthews, Brian W.
影响因子：
5.6
作者：
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通讯作者：
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DOI：
10.1161/01.atv.0000245807.65714.0b
发表时间：
2006-12-01
影响因子：
8.7
作者：
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通讯作者：
de Muinck, Ebo D.
影响因子：
4.8
作者：
Alfalah, M;Krahn, MP;Lendeckel, U
通讯作者：
Lendeckel, U
影响因子：
4.6
作者：
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通讯作者：
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