Aminopeptidase N in arterial hypertension.
Aminopeptidase N in arterial hypertension.
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DOI：
10.1007/s10741-007-9061-y
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发表时间：
2008-09
影响因子：
4.6
通讯作者：
Danziger RS
中科院分区：
文献类型：
--
作者：
Danziger RS
氨基肽酶N(APN)或CD13是M1胞外酶家族中一种保守的II型完整膜锌依赖的金属蛋白酶。APN在肾脏和中枢神经系统中含量丰富。识别的底物包括血管紧张素III(Ang III)；神经肽，包括脑啡肽和内啡肽；以及激素，包括卡利丹和生长抑素。它在发育中表达，是白血病的单核细胞标志物，也是冠状病毒的受体。APN在调节动脉血压和高血压发病机制中的作用不断得到支持。在啮齿动物品系中，脑室内(i.c.v.)APN的输注量减少，而APN活性的抑制剂对血压有升压作用。中枢APN调节失调与自发性高血压大鼠高血压的发病机制有关。有证据表明，肾小管APN抑制钠流，在盐适应中发挥机制作用。在Dahl盐敏感大鼠中发现了ANP基因的功能多态性。APN对血压的影响很可能是通过调节Ang III到Ang IV的代谢来实现的。APN是调节人体动脉血压，还是高血压的治疗靶点，还有待于进一步探讨。
Aminopeptidase N (APN) or CD13 is a conserved type II integral membrane zinc-dependent metalloprotease in the M1 family of ectoenzymes. APN is abundant in the kidneys and central nervous system. Identified substrates include Angiotensin III (Ang III); neuropeptides, including enkephalins and endorphins; and homones, including kallidan and somatostatin. It is developmentally expressed, a myelomonocytic marker for leukemias, and a receptor for coronovirus. There is evolving support for APN in the regulation of arterial blood pressure and the pathogenesis of hypertension. In rodent strains, intracerebraventricular (i.c.v.) infusions of APN reduces, while inhibitors of APN activity have a pressor effect on blood pressure. Dysregulation of central APN has been linked to the pathogenesis of hypertension in the spontaneously hypertensive rat. There is evidence that renal tubule APN inhibits Na flux and plays a mechanistic role in salt-adaptation. A functional polymorphism of the ANP gene has been identified in the Dahl salt-sensitive rat. Signaling by APN impacting on blood pressure is likely mediated by regulation of the metabolism of Ang III to Ang IV. Whether APN regulates arterial blood pressure in humans or is a therapeutic target for hypertension are subjects for future exploration.
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影响因子：
2.1
作者：
Hallberg P;Lind L;Michaëlsson K;Kurland L;Kahan T;Malmqvist K;Ohman KP;Nyström F;Liljedahl U;Syvänen AC;Melhus H
通讯作者：
Melhus H
影响因子：
3.5
作者：
Goto, Y;Hattori, A;Tsujimoto, M
通讯作者：
Tsujimoto, M
影响因子：
3
作者：
Coleman, JKM;Krebs, LT;Wright, JW
通讯作者：
Wright, JW
影响因子：
3.3
作者：
BARNES, K;BOURNE, A;KENNY, AJ
通讯作者：
KENNY, AJ
影响因子：
2.9
作者：
BATT, CM;JENSEN, LL;WRIGHT, JW
通讯作者：
WRIGHT, JW