The Ground Zero of Organismal Life and Aging.
The Ground Zero of Organismal Life and Aging.
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DOI：
10.1016/j.molmed.2020.08.012
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发表时间：
2021-01
影响因子：
13.6
通讯作者：
Gladyshev, Vadim N.
中科院分区：
文献类型：
--
作者：
Gladyshev, Vadim N.
细胞可能会自然地进行或被迫过渡到一种具有较低生物年龄的状态，即恢复活力。例如体细胞转化为诱导多能干细胞和生殖系每一代的再生。我们假设这些过程汇聚到同一个“起点”，即胚胎中期状态，其特征是最低的生物年龄，有机体生命和衰老都是从这里开始的。它也可能与种型状态有关。“归零”模型阐明了衰老、发育、再生和去分化之间的关系，这些关系在整个生命过程中都是不同的。通过延长早期胚胎发生的返老还童阶段和编辑基因组，有可能实现比自然年龄更低的零起点生物年龄。
Cells may naturally proceed or be forced to transition to a state with a radically lower biological age, i.e. be rejuvenated. Examples are the conversion of somatic cells to induced pluripotent stem cells and rejuvenation of the germline with each generation. We posit that these processes converge to the same “ground zero”, the mid-embryonic state characterized by the lowest biological age where both organismal life and aging begin. It may also be related to the phylotypic state. The ground zero model clarifies the relationship between aging, development, rejuvenation, and de-differentiation, which are distinct throughout life. By extending the rejuvenation phase during early embryogenesis and editing the genome, it may be possible to achieve the biological age at the ground zero lower than that achieved naturally.
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影响因子：
16
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