A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation.
A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation.
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病原细菌触发上皮信号形成功能性细菌受体，介导肌动蛋白伪足的形成。
DOI：
10.1002/j.1460-2075.1996.tb00621.x
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
B. Finlay
中科院分区：
文献类型：
--
作者：
Ilan;Rosenshine;S. Ruschkowski;Markus Stein;D. Reinscheid;Scott D. MihIs;B. Finlay
肠致病性E.大肠杆菌（EPEC）是一类能诱导肌动蛋白聚集的细菌病原体。我们发现EPEC粘附于上皮细胞介导细菌下方指状伪足（最大10微米）的形成。这些富含肌动蛋白的结构还含有酪氨酸磷酸化的宿主蛋白，其集中在粘附的EPEC下方的伪足尖端。亲密的细菌粘附（和伪足的形成）发生后，才事先细菌诱导的酪氨酸磷酸化的上皮膜蛋白，Hp 90，然后直接与EPEC粘附素，内膜。这些相互作用导致细胞骨架成核和伪足形成。这是细菌病原体在上皮细胞中触发信号的第一个例子，该信号激活受体与特定细菌配体的结合活性以及随后的细胞骨架重排。
Enteropathogenic E. coli (EPEC) belongs to a group of bacterial pathogens that induce actin accumulation beneath adherent bacteria. We found that EPEC adherence to epithelial cells mediates the formation of fingerlike pseudopods (up to 10 microm) beneath bacteria. These actin‐rich structures also contain tyrosine phosphorylated host proteins concentrated at the pseudopod tip beneath adherent EPEC. Intimate bacterial adherence (and pseudopod formation) occurred only after prior bacterial induction of tyrosine phosphorylation of an epithelial membrane protein, Hp90, which then associates directly with an EPEC adhesin, intimin. These interactions lead to cytoskeletal nucleation and pseudopod formation. This is the first example of a bacterial pathogen that triggers signals in epithelial cells which activates receptor binding activity to a specific bacterial ligand and subsequent cytoskeletal rearrangement.
DOI：
10.1073/pnas.87.20.7839
发表时间：
1990-10-01
影响因子：
11.1
作者：
JERSE, AE;YU, J;KAPER, JB
通讯作者：
KAPER, JB
DOI：
10.1073/pnas.92.17.7996
发表时间：
1995-08-15
影响因子：
11.1
作者：
JARVIS, KG;GIRON, JA;KAPER, JB
通讯作者：
KAPER, JB
细胞外基质对膜细胞骨架的图案化。
DOI：
--
发表时间：
1990
期刊：
Seminars in cell biology
影响因子：
--
作者：
Otey,CA;Burridge,K
通讯作者：
Burridge,K