Reciprocal amygdala–prefrontal interactions in learning
Reciprocal amygdala–prefrontal interactions in learning
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学习中杏仁核与前额叶的相互作用
DOI：
10.1016/j.conb.2018.06.006
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发表时间：
2018
影响因子：
5.7
通讯作者：
O. Klavir
中科院分区：
文献类型：
--
作者：
O. Yizhar;O. Klavir
动物不断地评估它们的环境，以避免潜在的威胁，并以食物，住所和社会互动的形式获得奖励。为了对来自环境的感官线索做出适当的反应，大脑需要形成和存储多个线索-结果关联。然后，这些可以用来预测声音、气味和其他来自周围环境的感官输入的效价。然而，这些关联必须不断更新，因为环境可能会迅速变化。不适应这种变化可能会对生存不利。哺乳动物大脑中的几个系统已经进化到执行这些重要的行为功能。在这些系统中，杏仁核和前额皮质是主要的参与者。虽然杏仁核已经被证明可以形成强烈的线索-结果关联，但前额叶皮层对于通过消退和逆转学习来修改这些关联是必不可少的，并且在这些结构之间的强烈相互连接中发生的突触可塑性被认为是适应性学习和适应不良学习的基础。在这里，我们回顾了杏仁核-前额叶回路的突触组织，并总结了其参与食欲和厌恶学习的生理和行为证据。
Animals constantly evaluate their environment in order to avoid potential threats and obtain reward in the form of food, shelter and social interactions. In order to appropriately respond to sensory cues from the environment, the brain needs to form and store multiple cue–outcome associations. These can then be used to form predictions of the valence of sounds, smells and other sensory inputs arising from the surroundings. However, these associations must be subject to constant update, as the environment can rapidly change. Failing to adapt to such change can be detrimental to survival. Several systems in the mammalian brain have evolved to perform these important behavioral functions. Among these systems, the amygdala and prefrontal cortex are prominent players. Although the amygdala has been shown to form strong cue–outcome associations, the prefrontal cortex is essential for modifying these associations through extinction and reversal learning, and synaptic plasticity occurring in the strong reciprocal connections between these structures is thought to underlie both adaptive and maladaptive learning. Here we review the synaptic organization of the amygdala–prefrontal circuit, and summarize the physiological and behavioral evidence for its involvement in appetitive and aversive learning.
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前额叶皮层驱动杏仁核基底外侧的不同投射神经元
影响因子：
8.8
作者：
McGarry LM;Carter AG
通讯作者：
Carter AG
影响因子：
3.7
作者：
McGinty, Vincent B.;Grace, Anthony A.
通讯作者：
Grace, Anthony A.
DOI：
--
发表时间：
--
期刊：
--
影响因子：
--
作者：
A. Pearson;B. J. Johnson;C. Wilmot;D. Ohlendorf;Jin-Hee Han;S. Kushner;A. Yiu;C. J. Cole;Alcino J. Silva;S. Josselyn
通讯作者：
A. Pearson;B. J. Johnson;C. Wilmot;D. Ohlendorf;Jin-Hee Han;S. Kushner;A. Yiu;C. J. Cole;Alcino J. Silva;S. Josselyn
影响因子：
13.9
作者：
Salzman CD;Fusi S
通讯作者：
Fusi S
影响因子：
5.7
作者：
Ghashghaei, Ht;Hilgetag, C. C.;Barbas, H.
通讯作者：
Barbas, H.