Activated Tumor-infiltrating Fibroblasts Predict Worse Prognosis in Breast Cancer Patients.
Activated Tumor-infiltrating Fibroblasts Predict Worse Prognosis in Breast Cancer Patients.
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激活的肿瘤浸润成纤维细胞预示乳腺癌患者预后较差
DOI：
10.7150/jca.28054
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发表时间：
2018
影响因子：
3.9
通讯作者：
Chen W
中科院分区：
文献类型：
--
作者：
Hu G;Xu F;Zhong K;Wang S;Huang L;Chen W
目的：活化的肿瘤浸润成纤维细胞与癌症患者的生存率显著相关。然而，它们是异质性群体，并且这些细胞在人类乳腺癌中的预后作用仍然存在争议。在此，我们进行了荟萃分析，以更好地了解这些细胞在乳腺癌患者预后预测中的作用。研究方法：我们检索PubMed和EBSCO，以确定评价免疫组化（IHC）方法检测的瘤内活化成纤维细胞密度与乳腺癌患者总生存期（OS）和/或无病生存期（DFS）相关性的研究，然后使用STATA 12.0计算提取数据的OS、DFS和临床病理特征（如淋巴结转移、TNM分期）的风险比（HR）。结果：共有来自15篇已发表研究的3680例乳腺癌患者纳入本荟萃分析。我们发现，活化的成纤维细胞的浸润显着降低患者的总生存期（OS）和无病生存期（DFS）。在分层分析中，FSP-1+或podoplanin+成纤维细胞的高密度与OS恶化显著相关;而α-SMA+或podoplanin+成纤维细胞浸润与乳腺癌DFS恶化相关。此外，活化的肿瘤浸润成纤维细胞数量的增加与患者的淋巴结转移和肿瘤分化不良显著相关。结论：活化的成纤维细胞，特别是FSP-1+或podoplanin+成纤维细胞的浸润导致乳腺癌患者的临床结果更差，这意味着它是一种有价值的预后生物标志物，靶向它可能具有有效治疗的潜力。
Purpose: Activated tumor-infiltrating fibroblasts were significantly associated with survival of cancer patients. However, they are heterogeneous population, and the prognostic role of these cells in human breast cancer still remains controversial. Herein, we performed the meta-analysis to better understand the role of these cells in prognosis prediction for breast cancer patients. Methods: We searched PubMed and EBSCO to identify the studies evaluating the association of intratumoral activated fibroblast density detected by immunohistochemical (IHC) method and overall survival (OS) and/or disease-free survival (DFS) in breast cancer patients, then computed extracted data into hazard ratios (HRs) for OS, DFS and clinicopathological features such as lymph node metastasis, TNM stage with STATA 12.0. Results: A total of 3680 patients with breast cancer from 15 published studies were incorporated into this meta-analysis. We found that the infiltration of activated fibroblasts significantly decreased overall survival (OS) and disease-free survival (DFS) in patients. In stratified analyses, high density of FSP-1+ or podoplanin+ fibroblasts was significantly associated with worse OS; while α-SMA+ or podoplanin+ fibroblast infiltration was associated with worse DFS in breast cancer. In addition, elevated number of activated tumor-infiltrating fibroblasts significantly correlated with lymph node metastasis and poor tumor differentiation of patients. Conclusion: The infiltration of activated fibroblasts, especially the FSP-1+ or podoplanin+ fibroblasts leads to worse clinical outcome in breast cancer patients, implicating that it is a valuable prognostic biomarker and targeting it may have a potential for effective treatment.
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影响因子：
2.2
作者：
DerSimonian, Rebecca;Kacker, Raghu
通讯作者：
Kacker, Raghu
DOI：
10.1084/jem.20140692
发表时间：
2014-07-28
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Öhlund D;Elyada E;Tuveson D
通讯作者：
Tuveson D
影响因子：
64.5
作者：
Boire, A;Covic, L;Kuliopulos, A
通讯作者：
Kuliopulos, A
DOI：
10.1073/pnas.1109493108
发表时间：
2011-09-20
影响因子：
11.1
作者：
O'Connell, Joyce T.;Sugimoto, Hikaru;Kalluri, Raghu
通讯作者：
Kalluri, Raghu
影响因子：
20.8
作者：
KURITZ, SJ;LANDIS, JR;KOCH, GG
通讯作者：
KOCH, GG