A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements.
A comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements.
复制标题
全面的实验和计算框架，用于临时磨损的总膝盖置换。
DOI：
10.1016/j.jmbbm.2017.11.022
复制
发表时间：
2018-03
影响因子：
3.9
通讯作者：
Jennings LM
中科院分区：
文献类型：
--
作者：
Abdelgaied A;Fisher J;Jennings LM
需要一个更强大的临床前佩戴模拟框架，以模拟在不同患者群体中观察到的更广泛和更高范围的活动，例如更年轻、更活跃的患者。这样的框架将有助于理解和解决报告的较高失败率的年轻和更活跃的患者。本研究为全膝关节置换术(TKR)的临床前磨损模拟开发和验证了一个综合的实验和计算框架。中交联型超高相对分子质量聚乙烯(UHMWPE)轴承材料的输入力学参数(弹性模量和泊松比)和磨损参数是在实际测试条件下通过实验研究独立测量的，类似于全膝关节置换中的加载条件。在一项独立的实验磨损模拟研究中，计算磨损模拟的磨损预测与3Sigma曲线型全膝关节置换术(英国DePuy)的直接实验磨损测量结果相比较，在三种不同的日常活动：步行、深蹲和爬楼梯的运动学条件下进行了验证。在拉伸试验条件下，测得的中等交联度UHMWPE材料的压缩力学性能比文献报道的低20%以上。中等交联度UHMWPE的销板磨损系数显著地依赖于关节面上的接触应力和横向剪切程度。目前框架下TKR的计算磨损预测与独立的全TKR实验磨损模拟测量结果一致，并与框架的决定系数为0.94。此外，综合的实验和计算相结合的框架能够解释所调查的三种不同日常活动的复杂的实验磨损趋势。因此，这样的框架可以被用作临床前模拟方法，以优化不同的设计、材料以及患者针对一系列活动的特定全膝关节置换。
A more robust pre-clinical wear simulation framework is required in order to simulate wider and higher ranges of activities, observed in different patient populations such as younger more active patients. Such a framework will help to understand and address the reported higher failure rates for younger and more active patients. The current study has developed and validated a comprehensive combined experimental and computational framework for pre-clinical wear simulation of total knee replacements (TKR). The input mechanical (elastic modulus and Poisson’s ratio) and wear parameters of the moderately cross-linked ultra-high molecular weight polyethylene (UHMWPE) bearing material were independently measured from experimental studies under realistic test conditions, similar to the loading conditions found in the total knee replacements. The wear predictions from the computational wear simulation were validated against the direct experimental wear measurements for size 3 Sigma curved total knee replacements (DePuy, UK) in an independent experimental wear simulation study under three different daily activities; walking, deep squat, and stairs ascending kinematic conditions. The measured compressive mechanical properties of the moderately cross-linked UHMWPE material were more than 20% lower than that reported in the literature under tensile test conditions. The pin-on-plate wear coefficient of moderately cross-linked UHMWPE was significantly dependant of the contact stress and the degree of cross-shear at the articulating surfaces. The computational wear predictions for the TKR from the current framework were consistent and in a good agreement with the independent full TKR experimental wear simulation measurements, with 0.94 coefficient of determination of the framework. In addition, the comprehensive combined experimental and computational framework was able to explain the complex experimental wear trends from the three different daily activities investigated. Therefore, such a framework can be adopted as a pre-clinical simulation approach to optimise different designs, materials, as well as patient’s specific total knee replacements for a range of activities.
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DOI：
10.1177/0954411917696519
发表时间：
2017-07
期刊：
Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine
影响因子：
--
作者：
Abdelgaied A;Fisher J;Jennings LM
通讯作者：
Jennings LM
影响因子：
2.4
作者：
Godest, AC;Beaugonin, M;Gregson, PJ
通讯作者：
Gregson, PJ
影响因子：
2.4
作者：
Fregly, BJ;Sawyer, WG;Banks, SA
通讯作者：
Banks, SA
影响因子：
4.2
作者：
Fisher, John;Jennings, Louise M.;Ingham, Eileen
通讯作者：
Ingham, Eileen
影响因子：
8.4
作者：
Carr, Brandi C.;Goswami, Tarun
通讯作者：
Goswami, Tarun