Pyramidal tract neurons receptive to different forelimb joints act differently during locomotion.
Pyramidal tract neurons receptive to different forelimb joints act differently during locomotion.
复制标题
接受不同前肢关节的锥体束神经元在运动过程中表现不同。
DOI：
10.1152/jn.00650.2011
复制
发表时间：
2012
影响因子：
2.5
通讯作者：
Beloozerova,IrinaN
中科院分区：
文献类型：
--
作者：
Stout,ErikE;Beloozerova,IrinaN
在运动过程中，运动皮层神经元投射到锥体束（PTNs）放电密切相关的步伐。它们的放电如何根据它们影响的身体部位而变化还不清楚。在简单运动和阶梯运动中，我们比较了4组具有不同前肢关节体感感受野的PTNs的活动：1）45个接受肩部运动的PTNs，2）30个接受肘部运动的PTNs，3）40个接受腕部运动的PTNs，4）30个无反应的PTNs。在运动皮层中，传入输入源的位置与运动输出的目标之间存在着某种联系。在此基础上，我们推断前肢关节PTN的影响，从它的体感感受野。我们发现，不同的PTNs往往在运动过程中放电不同。在简单的运动肩相关的PTNs是最活跃的后期站姿/早期摆动，并从简单的阶梯运动过渡后，他们往往增加活动和步幅相关的调制，同时减少放电持续时间。肘部相关的PTNs是最活跃的后期摆动/早期的立场，通常不会改变活动，调制，或放电持续时间的阶梯。腕部相关的PTNs在摆动期间最活跃，并且在过渡到阶梯时经常减少活动并增加调制，同时减少放电持续时间。这些数据表明，在运动过程中，运动皮层使用不同的机制来控制肩膀，肘部和手腕。
During locomotion, motor cortical neurons projecting to the pyramidal tract (PTNs) discharge in close relation to strides. How their discharges vary based on the part of the body they influence is not well understood. We addressed this question with regard to joints of the forelimb in the cat. During simple and ladder locomotion, we compared the activity of four groups of PTNs with somatosensory receptive fields involving different forelimb joints:1) 45 PTNs receptive to movements of shoulder,2) 30 PTNs receptive to movements of elbow,3) 40 PTNs receptive to movements of wrist, and4) 30 nonresponsive PTNs. In the motor cortex, a relationship exists between the location of the source of afferent input and the target for motor output. On the basis of this relationship, we inferred the forelimb joint that a PTN influences from its somatosensory receptive field. We found that different PTNs tended to discharge differently during locomotion. During simple locomotion shoulder-related PTNs were most active during late stance/early swing, and upon transition from simple to ladder locomotion they often increased activity and stride-related modulation while reducing discharge duration. Elbow-related PTNs were most active during late swing/early stance and typically did not change activity, modulation, or discharge duration on the ladder. Wrist-related PTNs were most active during swing and upon transition to the ladder often decreased activity and increased modulation while reducing discharge duration. These data suggest that during locomotion the motor cortex uses distinct mechanisms to control the shoulder, elbow, and wrist.
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