Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients.
Distinct progression pattern of susceptibility MRI in the substantia nigra of Parkinson's patients.
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帕金森氏病患者的黑质中，易感性MRI的明显进展模式。
DOI：
10.1002/mds.27318
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Huang X
中科院分区：
文献类型：
--
作者：
Du G;Lewis MM;Sica C;He L;Connor JR;Kong L;Mailman RB;Huang X
易感性MRI可以捕捉帕金森病（PD）相关病理。本研究描绘了不同黑质（SN）区域的纵向变化。72名PD患者和62名对照组在基线和18个月时进行了研究。计算了密实树（SNc）和网状树（SNr）的R2*和定量敏感性图（QSM）值。混合效应模型比较PD对照组或不同病程PD亚组：早期（<1年，PDE）；中期（<5年，PDM）；和晚期（大约50年，PDL）。皮尔逊相关性评估影像和临床测量之间的关联。在基线时，所有PD患者SNc和SNr的R2*和QSM均较高（组效应，p≤0.003）。纵向上，SNc R2*显示PD比对照组增加更快（time×group, p=0.002），而QSM没有（p=0.668）。PD组与对照组的SNr R2*和QSM无显著差异（time×group, p≥0.084），但两者均呈纵向下降（时间效应，p≤0.004）。基线SNc R2*在所有PD亚组中均较高（组，p≤0.006），但仅PDL （time×group, p<0.0001）的升高明显更快，且与非运动症状的变化相关（r=0.746, p=0.002）。PDM和PDL的基线信噪比QSM较高（组，p≤0.002），但仅在PDL与运动体征变化相关时显示纵向下降（time×group, p=0.004） （r=0.837, p<0.001）。敏感性MRI显示SNc和SNr中PD进展的不同模式。不同的模式在晚期患者中尤为明显。这些发现可能解决了过去的争议，并对PD进展过程中的病理生理过程具有指导意义。
Susceptibility MRI may capture Parkinson's disease (PD)-related pathology. This study delineated longitudinal changes in different substantia nigra (SN) regions. Seventy-two PD patients and 62 Controls were studied at both baseline and 18 months. R2* and quantitative susceptibility mapping (QSM) values from the pars compacta (SNc) and reticulata (SNr) were calculated. Mixed-effects models compared Controls with PD or PD subgroups having different disease durations: early (<1 year, PDE); middle (<5 years, PDM); and late (>5 years, PDL). Pearson's correlation assessed associations between imaging and clinical measures. At baseline, R2* and QSM were higher in both the SNc and SNr in all PD patients (group effect, p≤0.003). Longitudinally, SNc R2* showed a faster increase in PD compared to Controls (time×group, p=0.002), whereas QSM did not (p=0.668). SNr R2* and QSM did not differ between PD and Controls (time×group, p≥0.084), although both decreased longitudinally (time effect, p≤0.004). Baseline SNc R2* was higher in all PD subgroups (group, p≤0.006), but showed a significantly faster increase only in PDL (time×group, p<0.0001) that correlated with changes in non-motor symptoms (r=0.746, p=0.002). Baseline SNr QSM was higher in PDM and PDL (group, p≤0.002), but showed a longitudinal decrease (time×group, p=0.004) only in PDL that correlated with changes in motor signs (r=0.837, p<0.001). Susceptibility MRI revealed distinct patterns of PD progression in the SNc and SNr. The different patterns are particularly clear in later stage patients. These findings may resolve past controversies, and have implications in the pathophysiological processes during PD progression.
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DOI：
10.1002/mds.26417
发表时间：
2016-03
期刊：
Movement disorders : official journal of the Movement Disorder Society
影响因子：
--
作者：
Du G;Liu T;Lewis MM;Kong L;Wang Y;Connor J;Mailman RB;Huang X
通讯作者：
Huang X
影响因子：
3.8
作者：
Palmer JL;Coats MA;Roe CM;Hanko SM;Xiong C;Morris JC
通讯作者：
Morris JC
DOI：
10.1093/brain/awx146
发表时间：
2017-08-01
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Burciu RG;Ofori E;Archer DB;Wu SS;Pasternak O;McFarland NR;Okun MS;Vaillancourt DE
通讯作者：
Vaillancourt DE
影响因子：
11
作者：
HUGHES, AJ;DANIEL, SE;LEES, AJ
通讯作者：
LEES, AJ
影响因子：
5.7
作者：
Avants BB;Tustison NJ;Song G;Cook PA;Klein A;Gee JC
通讯作者：
Gee JC