Effect comparisons among treatment measures on progression-free survival in patients with skull base chordomas: a retrospective study of 234 post-surgical cases
Effect comparisons among treatment measures on progression-free survival in patients with skull base chordomas: a retrospective study of 234 post-surgical cases
复制标题
颅底脊索瘤患者治疗措施对无进展生存期的效果比较：234例术后病例的回顾性研究
DOI：
10.1007/s00701-017-3261-6
复制
发表时间：
2017-07
影响因子：
2.4
通讯作者：
Zhang Junting
中科院分区：
文献类型：
--
作者：
Wang Liang;Tian Kaibing;Ma Junpeng;Wang Ke;Jia Guijun;Wu Zhen;Zhang Liwei;Zhang Junting;Wang Liang;Wang Ke;Jia Guijun;Wu Zhen;Zhang Liwei;Zhang Junting
骨基脊索瘤(SBC)是一种少见、难治性肿瘤，复发率高。我们的目的是调查不同治疗措施与无进展生存(PFS)结果之间的关系。分组后进行组间和组内比较，分析PFS的临床病理特征和平均估计PFS次数，并对预后因素进行统计学分析。结果除病理亚型(p=0.005)外，初发病例的初始治疗措施(n=180)被确定为影响肿瘤进展的独立因素(p=0.002)。大体全切除患者的平均PFS时间最好(109.5个月)。病灶内切除组术后无瘤生存时间(38.3个月)最短，与病灶内切除后辅助性放射治疗组(56.6个月)相比，差异有统计学意义(P=0.058)。对于复发组(n=54)，边缘切除(p=0.007)和辅助放疗(p=0.041)是PFS的独立保护因素。接受边缘切除加辅助放射治疗的患者平均PFS时间最长(60.3个月)。结论无论是原发病例还是复发病例，治疗措施对术后肿瘤进展至关重要。对于原发病例，大体全切除和辅助放射治疗为所有患者和那些接受了病灶内切除的患者提供了更多的PFS好处。边缘切除和辅助放射治疗被认为是原发肿瘤的通用治疗范例，当应用于复发肿瘤时也同样有效。
BackgroundSkull base chordoma (SBC) is a rare and refractory tumor with a high rate of relapse. We aimed to investigate the relationships between different treatment measures and progression-free survival (PFS) outcomes.MethodsData from 234 SBC patients from one institution were retrieved from a prospectively maintained database. After grouping, the clinicopathological features and mean estimated PFS times were subject to inter-group and intra-group comparisons, and prognostic factors of PFS were estimated by statistical analyses. Two typical primary patients who suffered from repeated tumor relapses are described.ResultsIn addition to pathological subtype (p= 0.005), the initial treatment measure for the primary cases (n= 180) was identified as an independent factor of tumor progression (p= 0.002). The patients with gross total resection exhibited the best mean estimated PFS time (109.5 months). Patients with intralesional resection exhibited the shortest PFS time (38.3 months), with an almost significant difference (p= 0.058) compared to those with adjuvant radiotherapy following intralesional resection (56.6 months). For the recurrent group (n= 54), marginal resection (p= 0.007) and adjuvant radiotherapy (p= 0.041) were confirmed as independent protective factors for PFS. The longest mean PFS time (60.3 months) was noted in those patients who received marginal resection followed by adjuvant radiotherapy.ConclusionsTreatment measures were crucial for post-surgical tumor progression in both primary and recurrent cases. For primary cases, gross total resection and adjuvant radiotherapy offered more PFS benefits to all patients and those who underwent intralesional resection. Marginal resection and adjuvant radiotherapy, which are proposed as a general treatment paradigm for primary tumors, were also equally effective when applied to relapsing tumors.
登录
查看更多内容
影响因子：
1.9
作者：
Ahmed, Raheel;Sheybani, Arshin;Hitchon, Patrick W.
通讯作者：
Hitchon, Patrick W.
影响因子：
4.8
作者：
Arman Jahangiri;A. Chin;J. Wagner;S. Kunwar;C. Ames;D. Chou;I. Barani;A. Parsa;M. McDermott
通讯作者：
Arman Jahangiri;A. Chin;J. Wagner;S. Kunwar;C. Ames;D. Chou;I. Barani;A. Parsa;M. McDermott
影响因子：
6.2
作者：
Smoll, Nicolas R.;Gautschi, Oliver P.;Weber, Damien C.
通讯作者：
Weber, Damien C.
238例颅底脊索瘤患者临床特征及手术结果的回顾性分析
影响因子：
4.1
作者：
Wang, Liang;Wu, Zhen;Zhang, Junting
通讯作者：
Zhang, Junting
影响因子：
15.9
作者：
Meng, Tong;Yin, Huabin;Xiao, Jianru
通讯作者：
Xiao, Jianru