Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis.
Widespread sensorimotor and frontal cortical atrophy in Amyotrophic Lateral Sclerosis.
复制标题
肌萎缩性侧硬化症中的广泛感觉运动和额叶皮质萎缩。
DOI：
10.1186/1471-2377-6-17
复制
发表时间：
2006-04-25
期刊：
影响因子：
2.6
通讯作者：
Peschel, Thomas
中科院分区：
文献类型：
--
作者：
Grosskreutz, Julian;Kaufmann, Joern;Fraedrich, Julia;Dengler, Reinhard;Heinze, Hans-Jochen;Peschel, Thomas
肌萎缩侧索硬化症（ALS）广泛的皮质萎缩已被描述在神经病理学研究。在传统和科学的神经影像学中，皮质萎缩的存在一直是一个有争议的问题。在使用计算机断层扫描、正电子发射断层扫描、质子磁共振波谱和常规T2加权和质子加权图像的研究中，结果各不相同。最近通过磁共振成像进行的形态学研究产生了关于ALS患者灰质和白色物质受累程度的相互矛盾的结果。作者使用优化的基于体素的形态测量作为无偏的全脑方法来检测区域灰质和白色物质体积之间的差异。根据El-Escorial标准诊断为ALS的17名患者和17名年龄匹配的对照接受了高分辨率解剖T1扫描。与对照组相比，ALS患者双侧中央前回和中央后回的区域灰质体积（GMV）减少，并延伸到双侧运动前区、顶叶和额叶（p < 0.05，校正为整个体积）。修订后的ALS功能评定量表显示，与背外侧前额叶皮层相对应的右侧额内侧回的GMV降低呈正相关。当研究灰色和白色物质密度图像时，未发现白色物质体积有显著差异。在ALS患者中，原发性感觉运动皮层萎缩可以被认为是该疾病的一个突出特征。支持ALS是一种多系统疾病的概念，我们的研究提供了进一步的证据，运动外参与是广泛的。缺乏相关性与常见的临床变量可能反映了这样一个事实，即异质性疾病过程的基础ALS。到目前为止，所有已发表的ALS形态学研究中的差异可能与患者队列的差异和数据分析过程的几个方法学因素有关。需要进行纵向研究以进一步阐明ALS病程中灰质和白色物质病理的时间进程和分布。
Widespread cortical atrophy in Amyotrophic Lateral Sclerosis (ALS) has been described in neuropathological studies. The presence of cortical atrophy in conventional and scientific neuroimaging has been a matter of debate. In studies using computertomography, positron emission tomography, proton magnetic resonance spectroscopy and conventional T2-weighted and proton-weighted images, results have been variable. Recent morphometric studies by magnetic resonance imaging have produced conflicting results regarding the extent of grey and white matter involvement in ALS patients. The authors used optimized voxel-based morphometry as an unbiased whole brain approach to detect differences between regional grey and white matter volumes. Seventeen patients with a diagnosis of ALS according to El-Escorial criteria and seventeen age-matched controls received a high resolution anatomical T1 scan. In ALS patients regional grey matter volume (GMV) reductions were found in the pre- and postcentral gyrus bilaterally which extended to premotor, parietal and frontal regions bilaterally compared with controls (p < 0.05, corrected for the entire volume). The revised ALS functional rating scale showed a positive correlation with GMV reduction of the right medial frontal gyrus corresponding to the dorsolateral prefrontal cortex. No significant differences were found for white matter volumes or when grey and white matter density images were investigated. There were no further correlations with clinical variables found. In ALS patients, primary sensorimotor cortex atrophy can be regarded as a prominent feature of the disease. Supporting the concept of ALS being a multisytem disorder, our study provides further evidence for extramotor involvement which is widespread. The lack of correlation with common clinical variables probably reflects the fact that heterogeneous disease processes underlie ALS. The discrepancy within all published morphometric studies in ALS so far may be related to differences in patient cohorts and several methodological factors of the data analysis process. Longitudinal studies are required to further clarify the time course and distribution of grey and white matter pathology during the course of ALS.
登录
查看更多内容
影响因子：
9.9
作者：
Abrahams, S;Leigh, PN;Goldstein, LH
通讯作者：
Goldstein, LH
影响因子：
6
作者：
Al Theys, P;Peeters, E;Robberecht, W
通讯作者：
Robberecht, W
影响因子：
9.9
作者：
Graham, JM;Papadakis, N;Griffiths, PD
通讯作者：
Griffiths, PD
影响因子：
12.7
作者：
Hamilton, RL;Bowser, R
通讯作者：
Bowser, R
影响因子：
4.4
作者：
Cedarbaum, JM;Stambler, N;Nakanishi, A
通讯作者：
Nakanishi, A