Annealing post-drawn polycaprolactone (PCL) nanofibers optimizes crystallinity and molecular alignment and enhances mechanical properties and drug release profiles
Annealing post-drawn polycaprolactone (PCL) nanofibers optimizes crystallinity and molecular alignment and enhances mechanical properties and drug release profiles
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拉伸后退火聚己内酯 (PCL) 纳米纤维可优化结晶度和分子排列，并增强机械性能和药物释放曲线
DOI：
10.1039/d1ma01183a
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发表时间：
2022
影响因子：
5
通讯作者：
Beachley, Vince
中科院分区：
文献类型：
--
作者：
Flamini, Matthew D.;Lima, Thamires;Corkum, Kerri;Alvarez, Nicolas J.;Beachley, Vince
后拉伸的PCL纳米纤维可以根据退火的温度和时间进行分子调谐，从而具有各种机械性能和药物释放谱，这对再生医学和药物输送应用具有重要意义。拉伸后聚己内酯（PCL）纳米纤维已被证明可以显著提高其机械性能。本文研究了退火对后拉伸PCL纳米纤维的影响。结果表明，室温储存和体内温度在数周内显著提高结晶度，近熔体高温退火在数分钟内显著提高结晶度和分子取向。采用退火和淬火方法对结晶动力学进行了评估。高温退火还提高了纤维的极限拉伸强度和韧性，并改变了模型药物在PCL纳米纤维中吸收的释放动力学从一阶到零阶。
Post-drawn PCL nanofibers can be molecularly tuned to have a variety of mechanical properties and drug release profiles depending on the temperature and time of annealing, which has implications for regenerative medicine and drug delivery applications. Post-drawing polycaprolactone (PCL) nanofibers has previously been demonstrated to drastically increase their mechanical properties. Here the effects of annealing on post-drawn PCL nanofibers are characterized. It is shown that room temperature storage and in vivo temperatures increase crystallinity significantly on the order of weeks, and that high temperature annealing near melt significantly increases crystallinity and molecular orientation on the order of minutes. The kinetics of crystallization were assessed using an anneal and quench approach. High temperature annealing also increased the ultimate tensile strength and toughness of the fibers and changed the release profile of a model drug absorbed in PCL nanofibers from first-order to zero-order kinetics.
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