Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions.
Polymer nanofibrous structures: Fabrication, biofunctionalization, and cell interactions.
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DOI：
10.1016/j.progpolymsci.2010.03.003
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发表时间：
2010-07-01
影响因子：
27.1
通讯作者：
Wen X
中科院分区：
文献类型：
--
作者：
Beachley V;Wen X
细胞外基质纤维(ECM)，如胶原、弹性蛋白和角蛋白，为细胞附着、增殖、迁移、分化以及最终细胞命运提供生物和物理支持。因此，细胞外基质纤维是组织器官发育和再生的重要组成部分。同时，聚合物纳米纤维在组织再生过程中也可以发挥同样重要的作用。纤维结构可以用各种材料和方法制造，直径在整个尺寸范围内变化，细胞可以感知单个纤维(几纳米到几微米)。聚合物纳米纤维支架的设计方式可以预测地调节各种重要的细胞行为，以实现所需的整体功能。纳米纤维形态本身与纤维材料无关，已显示出调节组织工程中所需的细胞行为的潜力，如：单向排列；增加活性、附着和ECM产生；引导迁移；以及受控分化。生物分子功能化聚合物纳米纤维的多功能性为组织工程支架的设计带来了巨大的机遇，甚至可以更好地控制细胞的掺入和功能。尽管聚合物纳米纤维作为组织工程支架的前景看好，但由于目前没有一种单一的制造技术在保持合理的成本和产量的同时结合对结构排列、材料组成和生物功能化的控制，因此在临床上几乎没有成功的案例。目前正在研究有希望的策略，以允许制造最佳的聚合物纳米纤维组织工程支架，目标是在临床环境中治疗受损和退化的组织。
Extracellular matrix fibers (ECM) such as collagen, elastin, and keratin provide biological and physical support for cell attachment, proliferation, migration, differentiation and ultimately cell fate. Therefore, ECM fibers are an important component in tissue and organ development and regeneration. Meanwhile, polymer nanofibers could play the same critical role in tissue regeneration process. Fibrous structures can be fabricated from a variety of materials and methods with diameters ranging throughout the size scale where cells can sense individual fibers (several nanometers to several microns). Polymer nanofiber scaffolds can be designed in a way that predictably modulates a variety of important cell behaviors towards a desired overall function. The nanofibrous topography itself, independent of the fiber material, has demonstrated the potential to modulate cell behaviors desirable in tissue engineering such as: unidirectional alignment; increased viability, attachment, and ECM production; guided migration; and controlled differentiation. The versatility of polymer nanofibers for functionalization with biomolecules opens the door to vast opportunities for the design of tissue engineering scaffolds with even greater control over cell incorporation and function. Despite the promise of polymer nanofibers as tissue engineering scaffolds there have been few clinically relevant successes because no single fabrication technique currently combines control over structural arrangement, material composition, and biofunctionalization, while maintaining reasonable cost and yield. Promising strategies are currently being investigated to allow for the fabrication of optimal polymer nanofiber tissue engineering scaffolds with the goal of treating damaged and degenerated tissues in a clinical setting.
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影响因子：
3.1
作者：
Boland, ED;Matthews, JA;Bowlin, GL
通讯作者：
Bowlin, GL
DOI：
10.1016/j.msec.2009.07.008
发表时间：
2009-10-15
影响因子：
7.9
作者：
Beachley, Vince;Wen, Xuejun
通讯作者：
Wen, Xuejun
影响因子：
9.7
作者：
Chong, E. J.;Phan, T. T.;Lim, C. T.
通讯作者：
Lim, C. T.
影响因子：
4.1
作者：
Bashur, Chris A.;Shaffer, Robyn D.;Goldstein, Aaron S.
通讯作者：
Goldstein, Aaron S.
影响因子：
14
作者：
Chua, Kian-Ngiap;Chai, Chou;Mao, Hai-Quan
通讯作者：
Mao, Hai-Quan