Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages.
Layered protein nanoparticles containing influenza B HA stalk induced sustained cross-protection against viruses spanning both viral lineages.
复制标题
DOI：
10.1016/j.biomaterials.2022.121664
复制
发表时间：
2022-08
期刊：
影响因子：
14
通讯作者：
中科院分区：
文献类型：
--
作者：
流感流行对公众健康构成重大威胁。其中，B型流感与几次严重的流感暴发同时发生。由于流行毒株的抗原性变化，目前季节性流感疫苗的效力有限。在这项研究中，我们从B型流感病毒中产生了结构稳定的HA茎抗原，并制备了双层蛋白纳米颗粒作为通用的B型流感疫苗候选物。体外研究发现，所产生的蛋白质纳米颗粒被有效地吸收以激活树突状细胞。纳米颗粒免疫诱导广泛的反应性免疫应答，赋予针对两种谱系的流感B病毒株的稳健和持续的交叉免疫保护。结果揭示了与结构稳定的恒定抗原结合的层状蛋白纳米颗粒作为具有改善的免疫保护效力和广度的通用流感疫苗的潜力。
The influenza epidemics pose a significant threat to public health. Of them, type B influenza coincided with several severe flu outbreaks. The efficacy of the current seasonal flu vaccine is limited due to the antigenicity changes of circulating strains. In this study, we generated structure-stabilized HA stalk antigens from influenza B and fabricated double-layered protein nanoparticles as universal influenza B vaccine candidates. In vitro studies found that the resulting protein nanoparticles were effectively taken up to activate dendritic cells. Nanoparticle immunization induced broadly reactive immune responses conferring robust and sustained cross-immune protection against influenza B virus strains of both lineages. The results reveal the potential of layered protein nanoparticles incorporated with structure-stabilized constant antigens as a universal influenza vaccine with improved immune protective potency and breadth.
登录
查看更多内容
影响因子：
8
作者：
Eliasson, D. G.;Omokanye, A.;Lycke, N.
通讯作者：
Lycke, N.
影响因子：
8
作者：
Kelly, Hannah G.;Tan, Hyon-Xhi;Wheatley, Adam K.
通讯作者：
Wheatley, Adam K.
影响因子：
5.3
作者：
Deng L;Wang BZ
通讯作者：
Wang BZ
影响因子：
7.3
作者：
Del Campo J;Bouley J;Chevandier M;Rousset C;Haller M;Indalecio A;Guyon-Gellin D;Le Vert A;Hill F;Djebali S;Leverrier Y;Marvel J;Combadière B;Nicolas F
通讯作者：
Nicolas F
影响因子：
4.4
作者：
DiMenna, Lauren;Latimer, Brian;Ertl, Hildegund C. J.
通讯作者：
Ertl, Hildegund C. J.