The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.
The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans.
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DOI：
10.1084/jem.20090681
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发表时间：
2009-07-06
期刊：
影响因子：
--
通讯作者：
Levin SD
中科院分区：
文献类型：
--
作者：
Brandt CS;Baratin M;Yi EC;Kennedy J;Gao Z;Fox B;Haldeman B;Ostrander CD;Kaifu T;Chabannon C;Moretta A;West R;Xu W;Vivier E;Levin SD
癌症发展通常与免疫系统缺乏对肿瘤细胞的特异性和有效识别有关。自然杀伤（NK）细胞是参与消除肿瘤的先天免疫系统的淋巴细胞。我们报告了一种结合NKp 30的肿瘤细胞表面分子的鉴定，NKp 30是一种触发抗肿瘤NK细胞细胞毒性和细胞因子分泌的人类受体。这个以前未注释的基因属于B7家族，因此被命名为B7-H6。B7-H6触发NKp 30介导的人NK细胞活化。B7-H6在正常人体组织中未检测到，但在人肿瘤细胞上表达，强调了与细胞转化相关的应激诱导的自身分子的表达作为先天免疫中的细胞识别模式。
Cancer development is often associated with the lack of specific and efficient recognition of tumor cells by the immune system. Natural killer (NK) cells are lymphocytes of the innate immune system that participate in the elimination of tumors. We report the identification of a tumor cell surface molecule that binds NKp30, a human receptor which triggers antitumor NK cell cytotoxicity and cytokine secretion. This previously unannotated gene belongs to the B7 family and, hence, was designated B7-H6. B7-H6 triggers NKp30-mediated activation of human NK cells. B7-H6 was not detected in normal human tissues but was expressed on human tumor cells, emphasizing that the expression of stress-induced self-molecules associated with cell transformation serves as a mode of cell recognition in innate immunity.
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影响因子：
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作者：
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通讯作者：
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影响因子：
20.3
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