Focused ultrasound effects on nerve action potential in vitro.
Focused ultrasound effects on nerve action potential in vitro.
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DOI：
10.1016/j.ultrasmedbio.2009.05.002
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发表时间：
2009-10
影响因子：
2.9
通讯作者：
Hynynen, Kullervo
中科院分区：
文献类型：
--
作者：
Colucci, Vincent;Strichartz, Gary;Jolesz, Ferenc;Vykhodtseva, Natalia;Hynynen, Kullervo
关键词：
热能和机械能在人体解剖结构中的最低侵入性应用导致了对典型的手术干预的恢复和恢复的重大进展长期以来，对使用这种局灶性能量传递来阻止神经传导进行疼痛控制和局部麻醉。研究以进一步扩展我们对这一潜在临床应用的了解。
对牛蛙（Rana catesbeiana）的坐骨神经进行了焦点超声（在0.661MHz和1.986MHz的频率下），并显示出加热的铃声溶液。神经。通过社会室的循环冷却液可以防止神经作用的崩溃，但需要更高的功率来诱导与没有冷却的相同的终点。临时或永久。
Minimally invasive applications of thermal and mechanical energy to selective areas of the human anatomy have led to significant advances in treatment of and recovery from typical surgical interventions. Image-guided focused ultrasound allows energy to be deposited deep into the tissue, completely noninvasively. There has long been interest in using this focal energy delivery to block nerve conduction for pain control and local anesthesia. In this study, we have performed an in vitro study to further extend our knowledge of this potential clinical application. The sciatic nerves from the bullfrog (Rana catesbeiana) were subjected to focused ultrasound (at frequencies of 0.661MHz and 1.986MHz) and to heated Ringer’s solution. The nerve action potential was shown to decrease in the experiments and correlated with temperature elevation measured in the nerve. The action potential recovered either completely, partially, or not at all, depending on the parameters of the ultrasound exposure. The reduction of the baseline nerve temperature by circulating cooling fluid through the sonication chamber did not prevent the collapse of the nerve action potential; but higher power was required to induce the same endpoint as without cooling. These results indicate that a thermal mechanism of focused ultrasound can be used to block nerve conduction, either temporarily or permanently.
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影响因子：
3.5
作者：
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通讯作者：
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影响因子：
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作者：
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