Molecular cloning of canine RCAS1 cDNA.

Molecular cloning of canine RCAS1 cDNA.
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犬 RCAS1 cDNA 的分子克隆。

DOI:
10.1292/jvms.65.913
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发表时间:
2003
期刊:
The Journal of veterinary medical science
影响因子:
--
通讯作者:
Y. Taura
Y. Taura
中科院分区:
--
文献类型:
--
作者:
Y. Okamura;Zhiyong Ma;T. Khatlani;M. Okuda;S. Une;M. Nakaichi;Y. Taura

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SiSo细胞上表达的受体结合癌抗原(RCAS1)是一种新型的癌细胞表面抗原,在侵袭性癌症中强烈表达。RCAS1抑制免疫细胞体外生长,诱导凋亡细胞死亡。从犬乳腺肿瘤中克隆并鉴定了犬RCAS1 cDNA。犬RCAS1 cDNA全长864 bp,开放阅读框全长642 bp,编码213个氨基酸。预测的犬RCAS1氨基酸序列与人和小鼠RCAS1的同源性分别为96.2%和96.7%。犬RCAS1具有n端跨膜段和c端蛋白卷曲卷曲结构,在小鼠和人RCAS1中高度保守。
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a novel cancer cell-surface antigen, strongly expressed in invasive cancers. RCAS1 inhibited the in vitro growth of immunocytes, and induced apoptotic cell death. The cloning of canine RCAS1 cDNA was carried out and identified from the mammary gland tumor of a dog. A canine RCAS1 cDNA of 864 bp in length has an open reading frame of 642 bp nucleotides encoding a protein of 213 deduced amino acids. The predicted amino acid sequence of canine RCAS1 showed 96.2% and 96.7% homologies with those of human and mouse RCAS1 respectively. Canine RCAS1 has an N-terminal transmembrane segment and a coiled-coil structure in the C-terminal protein, which are highly conserved in mouse and human RCAS1.
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者:
西中川拓也、園田顕三;他
通讯作者: 他
K. Sonoda、M. Nakashima、T. Watanabe 等人:“一种在人类子宫癌和卵巢癌上表达的新型肿瘤相关抗原”癌症。
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发表时间: --
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DOI: 10.1006/gyno.2000.5981
发表时间: 2000-12-01
影响因子: 4.7
作者:
Sonoda, K;Kaku, T;Nakano, H
通讯作者: Nakano, H