Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network.
Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network.
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DOI：
10.1038/msb.2010.23
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发表时间：
2010-05-11
影响因子：
9.9
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中科院分区：
文献类型：
--
作者：
基因调控网络（GRN）提供了对系统水平差异基因表达机制的深入了解。与后生动物发育相关的 GRN 已被广泛研究。然而，对于控制新陈代谢、体内平衡和对环境线索的反应等生理过程的 GRN 的设计原理、组织和功能仍然知之甚少。在这项研究中，我们报告了第一个通过实验绘制的秀丽隐杆线虫代谢基因的后生动物GRN。该网络富含核激素受体（NHR）。线虫中的 NHR 家族已大大扩展：人类有 48 个 NHR，但线虫有 284 个，其中大部分是未知的。我们发现线虫代谢 GRN 是高度模块化的，并且两个 GRN 模块主要由 NHR 组成。网络模块化的提出是为了促进对不同线索的快速响应。由于 NHR 是能够对配体做出反应的代谢传感器，这表明秀丽隐杆线虫 GRN 通过 NHR 家族扩张和模块化 GRN 布线的同时进化，能够对不同的线索做出快速和适应性的反应。
Gene regulatory networks (GRNs) provide insights into the mechanisms of differential gene expression at a systems level. GRNs that relate to metazoan development have been studied extensively. However, little is still known about the design principles, organization and functionality of GRNs that control physiological processes such as metabolism, homeostasis and responses to environmental cues. In this study, we report the first experimentally mapped metazoan GRN of Caenorhabditis elegans metabolic genes. This network is enriched for nuclear hormone receptors (NHRs). The NHR family has greatly expanded in nematodes: humans have 48 NHRs, but C. elegans has 284, most of which are uncharacterized. We find that the C. elegans metabolic GRN is highly modular and that two GRN modules predominantly consist of NHRs. Network modularity has been proposed to facilitate a rapid response to different cues. As NHRs are metabolic sensors that are poised to respond to ligands, this suggests that C. elegans GRNs evolved to enable rapid and adaptive responses to different cues by a concurrence of NHR family expansion and modular GRN wiring.
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