Gender diversity associated with patterns of brain activation seen in populations that experience childhood stress.
Gender diversity associated with patterns of brain activation seen in populations that experience childhood stress.
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DOI：
10.3389/fnint.2023.1084748
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发表时间：
2023
影响因子：
3.5
通讯作者：
Potter, Alexandra
中科院分区：
文献类型：
--
作者：
Loso, Hannah;Chaarani, Bader;Dube, Sarahjane Locke;Albaugh, Matthew D.;Cheaito, Aya;Garavan, Hugh;Potter, Alexandra
童年的压力经历与情绪处理过程中独特的大脑活动模式有关。具体来说，儿童压力与岛叶、上级颞回和海马旁回以及杏仁核的激活有关，同时也与观察情绪面孔时背侧前扣带皮层的差异激活有关。性别多样性与9/10岁儿童的更高受害率和心理健康差异广泛相关，但它是否与脑功能的压力样改变（基于任务的功能磁共振成像期间的BOLD信号）相关仍不清楚。我们研究了这种关系的大脑功能相关性，以确定性别多样化的青年在情感任务中是否表现出与其他经历高度压力的人群一致的功能活动模式。我们使用了青少年大脑认知发展（ABCD）研究的数据。首先，我们确定了4,385名年龄在10/11岁的参与者的子集，这些参与者具有性别多样性数据和EN-Back（情绪n-back）任务的质量控制fMRI数据。EN-Back是一项工作记忆任务，它将情感面孔和地点的图片作为控制刺激。我们回归BOLD信号与情绪面孔（面孔减去地方对比）的性别多样性。接下来，我们测试了父母的接受或青少年对学校环境的看法是否会调节性别多样性与岛叶或梭状回激活之间的关系。最后，我们使用结构方程模型来研究性别多样性与父母的接受，学校环境的看法，内化和外化的问题。在EN-Back任务的面部条件下，性别多样性与BOLD信号的广泛增加相关。青少年的父母接受和学校环境的报告并没有调节性别多样性和梭状回BOLD信号之间的关系。性别多样性与更大的父母和学校相关的压力有关，这与心理健康问题的增加有关。功能活动的模式是一致的，在以前的文献报道的儿童压力。性别多样性与情绪和行为问题的增加以及与父母和学校有关的压力有关。这些调查结果表明，家庭和学校环境对于支持性别多样化青年的福祉至关重要。
Stressful childhood experiences are associated with unique brain activity patterns during emotional processing. Specifically, pediatric stress is linked to activation in the insulae, superior temporal and parahippocampal gyri, and the amygdalae, as well as differential activation in the dorsal anterior cingulate cortex when viewing emotional faces. Gender diversity is broadly associated with higher victimization and mental health disparities in children aged 9/10, but whether it is associated with stress-like alterations in brain function (BOLD signal during task-based fMRI) remains unknown. We investigate the functional brain correlates of this relationship to determine if gender-diverse youth show patterns of functional activity during an emotional task consistent with those of other populations that experience heightened stress. We used data from the Adolescent Brain Cognitive Development (ABCD)® study. First, we identified a subset of 4,385 participants aged 10/11 years with gender diversity data and quality-controlled fMRI data from the EN-Back (emotional n-back) task. The EN-Back is a working memory task that presents emotion faces as well as pictures of places as control stimuli. We regressed BOLD signal associated with emotion faces (faces minus places contrast) on gender diversity. Next, we tested if parental acceptance or youth perceptions of their school environment moderated the relationship between gender diversity and activation in the insulae or fusiform gyrus. Finally, we used structural equation modeling to investigate gender diversity’s association with parental acceptance, perceptions of school environments, internalizing and externalizing problems. Gender diversity was associated with widespread increases in BOLD signal during the faces condition of the EN-Back task. Youth’s report of parental acceptance and school environment did not moderate the relationship between gender diversity and BOLD signal in the insula or fusiform gyrus. Gender diversity was related to greater parent and school-related stress, which was associated with elevated mental health problems. Patterns of functional activity were consistent with those reported in prior literature on childhood stress. Gender diversity was associated with increased emotional and behavioral problems, as well as parent and school-related stress. These findings indicate the importance of the home and school environments for supporting the wellbeing of gender diverse youth.
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DOI：
10.1080/10705519909540118
发表时间：
1999-01-01
影响因子：
6
作者：
Hu, Li-tze;Bentler, Peter M.
通讯作者：
Bentler, Peter M.
影响因子：
25
作者：
Chaarani B;Hahn S;Allgaier N;Adise S;Owens MM;Juliano AC;Yuan DK;Loso H;Ivanciu A;Albaugh MD;Dumas J;Mackey S;Laurent J;Ivanova M;Hagler DJ;Cornejo MD;Hatton S;Agrawal A;Aguinaldo L;Ahonen L;Aklin W;Anokhin AP;Arroyo J;Avenevoli S;Babcock D;Bagot K;Baker FC;Banich MT;Barch DM;Bartsch H;Baskin-Sommers A;Bjork JM;Blachman-Demner D;Bloch M;Bogdan R;Bookheimer SY;Breslin F;Brown S;Calabro FJ;Calhoun V;Casey BJ;Chang L;Clark DB;Cloak C;Constable RT;Constable K;Corley R;Cottler LB;Coxe S;Dagher RK;Dale AM;Dapretto M;Delcarmen-Wiggins R;Dick AS;Do EK;Dosenbach NUF;Dowling GJ;Edwards S;Ernst TM;Fair DA;Fan CC;Feczko E;Feldstein-Ewing SW;Florsheim P;Foxe JJ;Freedman EG;Friedman NP;Friedman-Hill S;Fuemmeler BF;Galvan A;Gee DG;Giedd J;Glantz M;Glaser P;Godino J;Gonzalez M;Gonzalez R;Grant S;Gray KM;Haist F;Harms MP;Hawes S;Heath AC;Heeringa S;Heitzeg MM;Hermosillo R;Herting MM;Hettema JM;Hewitt JK;Heyser C;Hoffman E;Howlett K;Huber RS;Huestis MA;Hyde LW;Iacono WG;Infante MA;Irfanoglu O;Isaiah A;Iyengar S;Jacobus J;James R;Jean-Francois B;Jernigan T;Karcher NR;Kaufman A;Kelley B;Kit B;Ksinan A;Kuperman J;Laird AR;Larson C;LeBlanc K;Lessov-Schlagger C;Lever N;Lewis DA;Lisdahl K;Little AR;Lopez M;Luciana M;Luna B;Madden PA;Maes HH;Makowski C;Marshall AT;Mason MJ;Matochik J;McCandliss BD;McGlade E;Montoya I;Morgan G;Morris A;Mulford C;Murray P;Nagel BJ;Neale MC;Neigh G;Nencka A;Noronha A;Nixon SJ;Palmer CE;Pariyadath V;Paulus MP;Pelham WE;Pfefferbaum D;Pierpaoli C;Prescot A;Prouty D;Puttler LI;Rajapaske N;Rapuano KM;Reeves G;Renshaw PF;Riedel MC;Rojas P;de la Rosa M;Rosenberg MD;Ross MJ;Sanchez M;Schirda C;Schloesser D;Schulenberg J;Sher KJ;Sheth C;Shilling PD;Simmons WK;Sowell ER;Speer N;Spittel M;Squeglia LM;Sripada C;Steinberg J;Striley C;Sutherland MT;Tanabe J;Tapert SF;Thompson W;Tomko RL;Uban KA;Vrieze S;Wade NE;Watts R;Weiss S;Wiens BA;Williams OD;Wilbur A;Wing D;Wolff-Hughes D;Yang R;Yurgelun-Todd DA;Zucker RA;Potter A;Garavan HP;ABCD Consortium
通讯作者：
ABCD Consortium
影响因子：
4.7
作者：
Casey BJ;Cannonier T;Conley MI;Cohen AO;Barch DM;Heitzeg MM;Soules ME;Teslovich T;Dellarco DV;Garavan H;Orr CA;Wager TD;Banich MT;Speer NK;Sutherland MT;Riedel MC;Dick AS;Bjork JM;Thomas KM;Chaarani B;Mejia MH;Hagler DJ Jr;Daniela Cornejo M;Sicat CS;Harms MP;Dosenbach NUF;Rosenberg M;Earl E;Bartsch H;Watts R;Polimeni JR;Kuperman JM;Fair DA;Dale AM;ABCD Imaging Acquisition Workgroup
通讯作者：
ABCD Imaging Acquisition Workgroup
影响因子：
4.7
作者：
Barch DM;Albaugh MD;Avenevoli S;Chang L;Clark DB;Glantz MD;Hudziak JJ;Jernigan TL;Tapert SF;Yurgelun-Todd D;Alia-Klein N;Potter AS;Paulus MP;Prouty D;Zucker RA;Sher KJ
通讯作者：
Sher KJ
影响因子：
3.8
作者：
Landolt, MA;Bartholomew, K;Perlman, D
通讯作者：
Perlman, D