Alkaloids and phenolic glycosides from Clematis mandshurica and their inhibitory effects against NO production in LPS-induced RAW 246.7 macrophages
Alkaloids and phenolic glycosides from Clematis mandshurica and their inhibitory effects against NO production in LPS-induced RAW 246.7 macrophages
复制标题
铁线莲中的生物碱和酚苷及其对 LPS 诱导的 RAW 246.7 巨噬细胞 NO 产生的抑制作用
DOI：
10.1016/j.phytol.2016.08.005
复制
发表时间：
2016-09
影响因子：
1.7
通讯作者：
Zou Liang
中科院分区：
文献类型：
--
作者：
Fu Qiang;Chen Jiang;Yuan Hai-Mei;Ma Yu;Yu Tian;Zou Liang
从东北铁线莲（Clematis mandshurica）的根和根茎中分得两个新生物碱（1和2）、一个新酚苷（3）和五个已知结构（4 ~ 8）。根据光谱学证据和水解产物鉴定了它们的结构。评价所有分离株对RAW 246.7巨噬细胞中LPS诱导的一氧化氮（NO）产生的抑制活性。阿魏酸和异阿魏酸衍生物显示出中等的抑制作用，在50 μM时抑制率（%）为29.3 - 38.7，而3-羧基吲哚衍生物显示出强的抑制活性，IC 50为7.7 - 12.4 μM。
Two new alkaloids (1and2), one new phenolic glycoside (3), and five known structures (4⿿8) were isolated from the roots and rhizomes ofClematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidence and hydrolysis products. All isolates were evaluated for inhibitory activity against LPS-induced nitric oxide (NO) production in RAW 246.7 macrophages. Feruloyl and isoferuloyl derivates showed moderate inhibitory effects with the inhibition ratios (%) from 29.3 to 38.7 at 50 μM, whereas 3-carboxy-indole derivates showed potent inhibitory activities with IC50from 7.7 to 12.4 μM.
登录
查看更多内容
影响因子：
1.7
作者：
Shepo Shi;P. Tu;Caixia Dong;Dan Jiang
通讯作者：
Shepo Shi;P. Tu;Caixia Dong;Dan Jiang
影响因子：
1.7
作者：
Ling Li;Meiling Gou;Yu-xin He
通讯作者：
Ling Li;Meiling Gou;Yu-xin He
影响因子：
5.4
作者：
S. W. Lee;Sun-Mee Choi;Y. Chang;K. T. Kim;Tae Hyun Kim;H. Park;B. Park;You Jeong Sohn;S. Park;Su-Hyun Cho;W. Chung;Y. Yoo
通讯作者：
S. W. Lee;Sun-Mee Choi;Y. Chang;K. T. Kim;Tae Hyun Kim;H. Park;B. Park;You Jeong Sohn;S. Park;Su-Hyun Cho;W. Chung;Y. Yoo
影响因子：
5.1
作者：
Fu, Qiang;Zan, Ke;Tu, Pengfei
通讯作者：
Tu, Pengfei
影响因子：
5.6
作者：
M. G. Dilshara;Kyoung-tae Lee;Chang‐Min Lee;Yung-Hyun Choi;Hak-ju Lee;I. Choi;Gi-Young Kim
通讯作者：
M. G. Dilshara;Kyoung-tae Lee;Chang‐Min Lee;Yung-Hyun Choi;Hak-ju Lee;I. Choi;Gi-Young Kim