Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation.
Dilatory is a Drosophila protein related to AZI1 (CEP131) that is located at the ciliary base and required for cilium formation.
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DOI：
10.1242/jcs.084798
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发表时间：
2011-08-01
影响因子：
4
通讯作者：
Jarman AP
中科院分区：
文献类型：
--
作者：
Ma L;Jarman AP
已经发现大量的睫状体疾病基因编码定位于基底体的蛋白质。相比之下，大量的基体相关蛋白仍有待鉴定。在这里，我们报告了一个新的基体蛋白，是所需的果蝇纤毛发生的鉴定。Dilatory（DILA）是一种预测的卷曲螺旋蛋白，与脊椎动物AZI 1（也称为CEP 131）同源。dila基因突变特别表现出纤毛细胞（感觉神经元和精子）的缺陷。神经元表型的几个特征表明鞭毛内运输的缺陷。在感觉神经元纤毛中，DILA蛋白定位于纤毛基部，包括基体和假定的过渡区，并且它与纤毛卷曲螺旋蛋白不协调地遗传相互作用。这些数据暗示DILA在调节感觉纤毛基部的鞭毛内运输。
A significant number of ciliary disease genes have been found to encode proteins that localise to the basal body. By contrast, a large number of basal-body-associated proteins remain to be characterised. Here, we report the identification of a new basal body protein that is required for ciliogenesis in Drosophila. Dilatory (DILA) is a predicted coiled-coil protein homologous to vertebrate AZI1 (also known as CEP131). Mutations in dila specifically exhibit defects in ciliated cells (sensory neurons and sperm). Several features of the neuronal phenotype suggest a defect in intraflagellar transport. In sensory neuron cilia, DILA protein localises to the ciliary base, including the basal body and putative transition zone, and it interacts genetically with the ciliary coiled-coil protein, Uncoordinated. These data implicate DILA in regulating intraflagellar transport at the base of sensory cilia.
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影响因子：
3.3
作者：
Kavlie, Ryan G.;Kernan, Maurice J.;Eberl, Daniel F.
通讯作者：
Eberl, Daniel F.
DOI：
10.1083/jcb.201006105
发表时间：
2010-09-06
期刊：
The Journal of cell biology
影响因子：
--
作者：
Craige B;Tsao CC;Diener DR;Hou Y;Lechtreck KF;Rosenbaum JL;Witman GB
通讯作者：
Witman GB
影响因子：
64.8
作者：
Andersen, JS;Wilkinson, CJ;Mann, M
通讯作者：
Mann, M
影响因子：
4
作者：
Butcher, RDJ;Chodagam, S;Whitfield, WGF
通讯作者：
Whitfield, WGF
影响因子：
9.2
作者：
Deane, JA;Cole, DG;Rosenbaum, JL
通讯作者：
Rosenbaum, JL