Distinct neuroanatomic subtypes in antipsychotic-treated patients with schizophrenia classified by the predefined classification in a never-treated sample
Distinct neuroanatomic subtypes in antipsychotic-treated patients with schizophrenia classified by the predefined classification in a never-treated sample
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根据从未治疗样本中的预定义分类，接受抗精神病药物治疗的精神分裂症患者的不同神经解剖学亚型
DOI：
10.1093/psyrad/kkab018
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Su Lui
中科院分区：
文献类型：
--
作者：
Qiannan Zhao;Jiao Li;Yuan Xiao;Hengyi Cao;Xiao Wang;Wei Zhang;Siyi Li;Wei Liao;Qiyong Gong;Su Lui
摘要背景不同的神经解剖亚型已被确定在从未治疗过的精神分裂症患者的大脑结构异常的基础上，但抗精神病药物治疗的患者是否会分层的指导下，这种以前形成的分类仍不清楚。目的探讨抗精神病药物治疗后精神分裂症患者脑结构的改变及其与认知功能的关系。方法应用结构磁共振成像技术对147例精神分裂症患者进行脑皮质厚度、表面积和皮质下体积的测量。采用精神分裂症认知功能简明评定量表（BACS）和阳性与阴性症状量表（PANSS）评定患者的认知功能和症状。结果抗精神病药物治疗的患者可分为三种亚型，其脑形态学改变的模式各不相同。亚型1和2的特点是广泛的赤字皮质厚度，但相对有限的赤字表面积。相反，亚型3表现出皮质增厚，主要在顶枕区和广泛的赤字表面积。与健康对照组相比，所有三个亚组均表现出认知缺陷。仅在亚型1中观察到神经解剖学和认知异常之间的显著关联，其中左侧舌回的皮质变薄与符号编码性能相反。结论与药物初治患者相似，抗精神病药物治疗患者存在神经解剖异质性，与认知功能有不同的相关性。这些发现促进了我们对异质性背景下神经解剖异常与认知表现之间关系的理解。此外，这些结果表明，神经生物学的异质性需要考虑在精神分裂症的认知研究。
Abstract Background Distinct neuroanatomic subtypes have been identified in never-treated patients with schizophrenia based on cerebral structural abnormalities, but whether antipsychotic-treated patients would be stratified under the guidance of such previously formed classification remains unclear. Objective The present study aimed to investigate alterations of brain structures in antipsychotic-treated patients with schizophrenia based on a predefined morphological classification and their relationships with cognitive performance. Methods Cortical thickness, surface area, and subcortical volume were extracted from 147 antipsychotic-treated patients with schizophrenia using structural magnetic resonance imaging for classification. The Brief Assessment of Cognition in Schizophrenia (BACS) and Positive and Negative Syndrome Scale (PANSS) were used to assess cognition and symptoms. Results Antipsychotic-treated patients were categorized into three subtypes with distinct patterns of brain morphological alterations. Subtypes 1 and 2 were characterized by widespread deficits in cortical thickness but relatively limited deficits in surface area. In contrast, subtype 3 demonstrated cortical thickening mainly in parietal-occipital regions and widespread deficits in surface area. All three subgroups demonstrated cognitive deficits compared with healthy controls. Significant associations between neuroanatomic and cognitive abnormalities were only observed in subtype 1, where cortical thinning in the left lingual gyrus was conversely related to symbol coding performance. Conclusions Similar to drug-naïve patients, neuroanatomic heterogeneity exists in antipsychotic-treated patients, with disparate associations with cognition. These findings promote our understanding of relationships between neuroanatomic abnormalities and cognitive performance in the context of heterogeneity. Moreover, these results suggest that neurobiological heterogeneity needs to be considered in cognitive research in schizophrenia.
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DOI：
10.1016/b978-0-12-813866-3.00038-2
发表时间：
2020
期刊：
Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease
影响因子：
--
作者：
D. Volk;Aaron K. Jenkins;Paven A. Lidstone;D. Lewis
通讯作者：
D. Volk;Aaron K. Jenkins;Paven A. Lidstone;D. Lewis
影响因子：
3.2
作者：
Wang LJ;Lin PY;Lee Y;Huang YC;Hsu ST;Hung CF;Chen CK;Chen YC;Wang YL;Tsai MC
通讯作者：
Tsai MC
影响因子：
3.4
作者：
HALL, RCW
通讯作者：
HALL, RCW
DOI：
10.1176/appi.ajp.2013.12050674
发表时间：
2013-06
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Andreasen NC;Liu D;Ziebell S;Vora A;Ho BC
通讯作者：
Ho BC
影响因子：
10.6
作者：
van Erp TGM;Walton E;Hibar DP;Schmaal L;Jiang W;Glahn DC;Pearlson GD;Yao N;Fukunaga M;Hashimoto R;Okada N;Yamamori H;Bustillo JR;Clark VP;Agartz I;Mueller BA;Cahn W;de Zwarte SMC;Hulshoff Pol HE;Kahn RS;Ophoff RA;van Haren NEM;Andreassen OA;Dale AM;Doan NT;Gurholt TP;Hartberg CB;Haukvik UK;Jørgensen KN;Lagerberg TV;Melle I;Westlye LT;Gruber O;Kraemer B;Richter A;Zilles D;Calhoun VD;Crespo-Facorro B;Roiz-Santiañez R;Tordesillas-Gutiérrez D;Loughland C;Carr VJ;Catts S;Cropley VL;Fullerton JM;Green MJ;Henskens FA;Jablensky A;Lenroot RK;Mowry BJ;Michie PT;Pantelis C;Quidé Y;Schall U;Scott RJ;Cairns MJ;Seal M;Tooney PA;Rasser PE;Cooper G;Shannon Weickert C;Weickert TW;Morris DW;Hong E;Kochunov P;Beard LM;Gur RE;Gur RC;Satterthwaite TD;Wolf DH;Belger A;Brown GG;Ford JM;Macciardi F;Mathalon DH;O'Leary DS;Potkin SG;Preda A;Voyvodic J;Lim KO;McEwen S;Yang F;Tan Y;Tan S;Wang Z;Fan F;Chen J;Xiang H;Tang S;Guo H;Wan P;Wei D;Bockholt HJ;Ehrlich S;Wolthusen RPF;King MD;Shoemaker JM;Sponheim SR;De Haan L;Koenders L;Machielsen MW;van Amelsvoort T;Veltman DJ;Assogna F;Banaj N;de Rossi P;Iorio M;Piras F;Spalletta G;McKenna PJ;Pomarol-Clotet E;Salvador R;Corvin A;Donohoe G;Kelly S;Whelan CD;Dickie EW;Rotenberg D;Voineskos AN;Ciufolini S;Radua J;Dazzan P;Murray R;Reis Marques T;Simmons A;Borgwardt S;Egloff L;Harrisberger F;Riecher-Rössler A;Smieskova R;Alpert KI;Wang L;Jönsson EG;Koops S;Sommer IEC;Bertolino A;Bonvino A;Di Giorgio A;Neilson E;Mayer AR;Stephen JM;Kwon JS;Yun JY;Cannon DM;McDonald C;Lebedeva I;Tomyshev AS;Akhadov T;Kaleda V;Fatouros-Bergman H;Flyckt L;Karolinska Schizophrenia Project;Busatto GF;Rosa PGP;Serpa MH;Zanetti MV;Hoschl C;Skoch A;Spaniel F;Tomecek D;Hagenaars SP;McIntosh AM;Whalley HC;Lawrie SM;Knöchel C;Oertel-Knöchel V;Stäblein M;Howells FM;Stein DJ;Temmingh HS;Uhlmann A;Lopez-Jaramillo C;Dima D;McMahon A;Faskowitz JI;Gutman BA;Jahanshad N;Thompson PM;Turner JA
通讯作者：
Turner JA