Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis (ENIGMA) Consortium.
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DOI：
10.1016/j.biopsych.2018.04.023
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发表时间：
2018-11-01
影响因子：
10.6
通讯作者：
Turner JA
中科院分区：
文献类型：
--
作者：
van Erp TGM;Walton E;Hibar DP;Schmaal L;Jiang W;Glahn DC;Pearlson GD;Yao N;Fukunaga M;Hashimoto R;Okada N;Yamamori H;Bustillo JR;Clark VP;Agartz I;Mueller BA;Cahn W;de Zwarte SMC;Hulshoff Pol HE;Kahn RS;Ophoff RA;van Haren NEM;Andreassen OA;Dale AM;Doan NT;Gurholt TP;Hartberg CB;Haukvik UK;Jørgensen KN;Lagerberg TV;Melle I;Westlye LT;Gruber O;Kraemer B;Richter A;Zilles D;Calhoun VD;Crespo-Facorro B;Roiz-Santiañez R;Tordesillas-Gutiérrez D;Loughland C;Carr VJ;Catts S;Cropley VL;Fullerton JM;Green MJ;Henskens FA;Jablensky A;Lenroot RK;Mowry BJ;Michie PT;Pantelis C;Quidé Y;Schall U;Scott RJ;Cairns MJ;Seal M;Tooney PA;Rasser PE;Cooper G;Shannon Weickert C;Weickert TW;Morris DW;Hong E;Kochunov P;Beard LM;Gur RE;Gur RC;Satterthwaite TD;Wolf DH;Belger A;Brown GG;Ford JM;Macciardi F;Mathalon DH;O'Leary DS;Potkin SG;Preda A;Voyvodic J;Lim KO;McEwen S;Yang F;Tan Y;Tan S;Wang Z;Fan F;Chen J;Xiang H;Tang S;Guo H;Wan P;Wei D;Bockholt HJ;Ehrlich S;Wolthusen RPF;King MD;Shoemaker JM;Sponheim SR;De Haan L;Koenders L;Machielsen MW;van Amelsvoort T;Veltman DJ;Assogna F;Banaj N;de Rossi P;Iorio M;Piras F;Spalletta G;McKenna PJ;Pomarol-Clotet E;Salvador R;Corvin A;Donohoe G;Kelly S;Whelan CD;Dickie EW;Rotenberg D;Voineskos AN;Ciufolini S;Radua J;Dazzan P;Murray R;Reis Marques T;Simmons A;Borgwardt S;Egloff L;Harrisberger F;Riecher-Rössler A;Smieskova R;Alpert KI;Wang L;Jönsson EG;Koops S;Sommer IEC;Bertolino A;Bonvino A;Di Giorgio A;Neilson E;Mayer AR;Stephen JM;Kwon JS;Yun JY;Cannon DM;McDonald C;Lebedeva I;Tomyshev AS;Akhadov T;Kaleda V;Fatouros-Bergman H;Flyckt L;Karolinska Schizophrenia Project;Busatto GF;Rosa PGP;Serpa MH;Zanetti MV;Hoschl C;Skoch A;Spaniel F;Tomecek D;Hagenaars SP;McIntosh AM;Whalley HC;Lawrie SM;Knöchel C;Oertel-Knöchel V;Stäblein M;Howells FM;Stein DJ;Temmingh HS;Uhlmann A;Lopez-Jaramillo C;Dima D;McMahon A;Faskowitz JI;Gutman BA;Jahanshad N;Thompson PM;Turner JA
尽管发表了数百篇脑结构成像研究，但精神分裂症患者皮层神经解剖学异常的概况仍未完全了解。本研究是由ENIGMA（通过Meta分析增强神经成像遗传学）精神分裂症工作组对精神分裂症的皮质厚度和表面积异常进行的首次荟萃分析。该研究纳入了来自全球39个中心的4474名精神分裂症患者（平均年龄=32.3岁，范围：11-78岁，66%为男性）和5098名健康志愿者（平均年龄=32.8岁，范围：10-87岁，53%为男性）的数据，采用标准化方法进行评估。与健康志愿者相比，精神分裂症患者的皮层普遍较薄（左/右半球：Cohen’s d= - 0.530/ - 0.516），表面积较小（左/右半球：d= - 0.251/ - 0.254），额叶和颞叶区域的效应量最大。在对整体皮质厚度进行统计控制后，皮质厚度的区域组差异仍然显著，提示区域特异性。相反，对皮质表面积的影响是全局性的。病例对照，阴性，皮质厚度效应大小在抗精神病药物治疗相对于未用药个体大2至3倍。精神分裂症患者的年龄与双侧颞极厚度之间的负相关强于健康志愿者。区域皮质厚度与规范化用药剂量、症状严重程度和病程呈显著负相关，与发病年龄呈正相关。研究结果表明，ENIGMA荟萃分析方法可以在临床神经科学研究中获得可靠的发现；此外，在未来精神分裂症皮质厚度的遗传关联研究中，药物效应也应考虑在内。
The profile of cortical neuroanatomical abnormalities in schizophrenia is not fully understood, despite hundreds of published structural brain imaging studies. This study presents the first meta-analysis of cortical thickness and surface area abnormalities in schizophrenia conducted by the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta Analysis) Schizophrenia Working Group. The study included data from 4474 individuals with schizophrenia (mean age=32.3, range: 11–78; 66% male) and 5098 healthy volunteers (mean age=32.8, range: 10–87; 53% male), assessed with standardized methods, at 39 centers worldwide. Compared to healthy volunteers, individuals with schizophrenia have widespread thinner cortex (left/right hemisphere: Cohen’s d=−0.530/−0.516) and smaller surface area (left/right hemisphere: d=−0.251/−0.254), with the largest effect sizes for both in frontal and temporal lobe regions. Regional group differences in cortical thickness remained significant when statistically controlling for global cortical thickness, suggesting regional specificity. In contrast, the effects for cortical surface area appear global. Case-control, negative, cortical thickness effect sizes were 2 to 3 times larger in antipsychotic medicated relative to unmedicated individuals. Negative correlations between age and bilateral temporal pole thickness were stronger in individuals with schizophrenia than in healthy volunteers. Regional cortical thickness showed significant negative correlations with normalized medication dose, symptom severity, and duration of illness, and positive correlations with age at onset. The findings indicate that the ENIGMA meta-analysis approach can achieve robust findings in clinical neuroscience studies; also, medication effects should be taken into account in future genetic association studies of cortical thickness in schizophrenia.
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影响因子：
4.5
作者：
Hedman, Anna M.;van Haren, Neeltje E. M.;Pol, Hilleke E. Hulshoff
通讯作者：
Pol, Hilleke E. Hulshoff
影响因子：
--
作者：
Lieberman, JA;Tollefson, GD;Tohen, M
通讯作者：
Tohen, M
影响因子：
4.8
作者：
Fornito, Alex;Yucel, Murat;Panteliss, Christos
通讯作者：
Panteliss, Christos
影响因子：
5.7
作者：
Kabani, N;Le Goualher, G;Evans, AC
通讯作者：
Evans, AC
影响因子：
25.8
作者：
Lesh TA;Tanase C;Geib BR;Niendam TA;Yoon JH;Minzenberg MJ;Ragland JD;Solomon M;Carter CS
通讯作者：
Carter CS