Steroid-eluting contact lenses for corneal and intraocular inflammation.
Steroid-eluting contact lenses for corneal and intraocular inflammation.
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DOI：
10.1016/j.actbio.2020.08.013
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发表时间：
2020-10-15
影响因子：
9.7
通讯作者：
Ciolino JB
中科院分区：
文献类型：
--
作者：
Bengani LC;Kobashi H;Ross AE;Zhai H;Salvador-Culla B;Tulsan R;Kolovou PE;Mittal SK;Chauhan SK;Kohane DS;Ciolino JB
眼部炎症是全世界失明的主要原因之一，局部眼用溶液中的类固醇（例如地塞米松滴眼液）是治疗眼部炎症的主要方法。对于许多非传染性眼部炎症性疾病，例如葡萄膜炎，滴眼剂的频率为每小时一次。用药频率高，加上滴眼剂的副作用，导致患者依从性差。药物洗脱隐形眼镜长期以来一直被视为持续眼部药物输送的潜在更好替代品。但将足够的药物装入隐形眼镜并控制药物的释放仍然是一个挑战。先前通过将地塞米松聚合物薄膜封装在水凝胶隐形眼镜的外围开发了地塞米松释放隐形眼镜（Dex-Lens）。在这里，我们在兔子模型中证明了 Dex-Lens 治疗前眼部炎症的安全性和有效性。 Dex-Lens 在体内递送药物 7 天（兔子模型）。在一项使用 Dex-Lens 提取物的眼部刺激研究（Draize 试验）中，在正常兔眼中未观察到不良事件。 Dex-Lenses 可有效抑制缝线诱导的角膜新生血管和炎症 7 天，以及脂多糖诱导的前葡萄膜炎 5 天。 Dex-Lenses 的功效与每小时给药的地塞米松滴眼液相似。在角膜新生血管研究中，与佩戴 Dex-Lens 的兔子眼睛相比，未接受治疗的兔子眼睛和佩戴车辆镜片的兔子眼睛观察到严重的角膜水肿。在这些研究中，Dex-Lenses 的耐受性良好，并且没有表现出毒性迹象。地塞米松洗脱隐形眼镜可能是治疗眼部炎症的一种选择，也是眼部药物输送的平台。
Ocular inflammation is one of the leading causes of blindness worldwide, and steroids in topical ophthalmic solutions (e.g. dexamethasone eye drops) are the mainstay of therapy for ocular inflammation. For many non-infectious ocular inflammatory diseases, such as uveitis, eye drops are administered as often as once every hour. The high frequency of administration coupled with the side effects of eye drops leads to poor adherence for patients. Drug-eluting contact lenses have long been sought as a potentially superior alternative for sustained ocular drug delivery; but loading sufficient drug into contact lenses and control the release of the drug is still a challenge. A dexamethasone releasing contact lens (Dex-Lens) was previously developed by encapsulating a dexamethasone-polymer film within the periphery of a hydrogel-based contact lens. Here, we demonstrate safety and efficacy of the Dex-Lens in rabbit models in the treatment of anterior ocular inflammation. The Dex-Lens delivered drug for 7 days in vivo (rabbit model). In an ocular irritation study (Draize test) with Dex-Lens extracts, no adverse events were observed in normal rabbit eyes. Dex-Lenses effectively inhibited suture-induced corneal neovascularization and inflammation for 7 days and lipopolysaccharide-induced anterior uveitis for 5 days. The efficacy of Dex-Lenses was similar to that of hourly-administered dexamethasone eye drops. In the corneal neovascularization study, substantial corneal edema was observed in rabbit eyes that received no treatment and those that wore a vehicle lens as compared to rabbit eyes that wore the Dex-Lens. Throughout these studies, Dex-Lenses were well tolerated and did not exhibit signs of toxicity. Dexamethasone-eluting contact lenses may be an option for the treatment of ocular inflammation and a platform for ocular drug delivery.
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影响因子：
2.8
作者：
Epstein, Andrew J.;de Castro, Terla N.;Rapuano, Christopher J.
通讯作者：
Rapuano, Christopher J.
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