Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance.
Plasticity of Type I Interferon-Mediated Responses in Cancer Therapy: From Anti-tumor Immunity to Resistance.
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DOI：
10.3389/fonc.2018.00322
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发表时间：
2018
影响因子：
4.7
通讯作者：
Dolcetti R
中科院分区：
文献类型：
--
作者：
Budhwani M;Mazzieri R;Dolcetti R
针对癌症的几种治疗策略（包括细胞毒性药物、放射疗法、靶向免疫疗法和溶瘤病毒）的功效取决于完整的I型干扰素（IFN）信号传导以促进直接（肿瘤细胞抑制）和间接（抗肿瘤免疫应答）作用。肿瘤细胞或免疫细胞中该途径的功能障碍可能是缺乏反应或抵抗的原因。虽然I型IFN信号传导是触发抗肿瘤免疫所必需的，但新出现的证据表明I型IFN途径的慢性激活可能参与介导对不同癌症治疗的抗性。应仔细考虑I型IFN应答的塑性和动态特征，以充分利用靶向IFN信号传导的策略的治疗潜力。在这里，我们回顾现有的证据支持参与I型干扰素信号介导的各种癌症治疗的耐药性，并强调最有前途的方式，正在测试，以克服阻力。
The efficacy of several therapeutic strategies against cancer, including cytotoxic drugs, radiotherapy, targeted immunotherapies and oncolytic viruses, depend on intact type I interferon (IFN) signaling for the promotion of both direct (tumor cell inhibition) and indirect (anti-tumor immune responses) effects. Malfunctions of this pathway in tumor cells or in immune cells may be responsible for the lack of response or resistance. Although type I IFN signaling is required to trigger anti-tumor immunity, emerging evidence indicates that chronic activation of type I IFN pathway may be involved in mediating resistance to different cancer treatments. The plastic and dynamic features of type I IFN responses should be carefully considered to fully exploit the therapeutic potential of strategies targeting IFN signaling. Here, we review available evidence supporting the involvement of type I IFN signaling in mediating resistance to various cancer therapies and highlight the most promising modalities that are being tested to overcome resistance.
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影响因子：
64.5
作者：
Boelens MC;Wu TJ;Nabet BY;Xu B;Qiu Y;Yoon T;Azzam DJ;Twyman-Saint Victor C;Wiemann BZ;Ishwaran H;Ter Brugge PJ;Jonkers J;Slingerland J;Minn AJ
通讯作者：
Minn AJ
影响因子：
64.5
作者：
Benci JL;Xu B;Qiu Y;Wu TJ;Dada H;Twyman-Saint Victor C;Cucolo L;Lee DSM;Pauken KE;Huang AC;Gangadhar TC;Amaravadi RK;Schuchter LM;Feldman MD;Ishwaran H;Vonderheide RH;Maity A;Wherry EJ;Minn AJ
通讯作者：
Minn AJ
影响因子：
11.2
作者：
Burnette BC;Liang H;Lee Y;Chlewicki L;Khodarev NN;Weichselbaum RR;Fu YX;Auh SL
通讯作者：
Auh SL
影响因子：
8.8
作者：
Corrales L;Glickman LH;McWhirter SM;Kanne DB;Sivick KE;Katibah GE;Woo SR;Lemmens E;Banda T;Leong JJ;Metchette K;Dubensky TW Jr;Gajewski TF
通讯作者：
Gajewski TF
影响因子：
5.4
作者：
Bhat N;Fitzgerald KA
通讯作者：
Fitzgerald KA